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Description

Norverapamil, Hydrochloride · CAS 67018-85-3 · C26H36N2O4. UNII 957Z3K3R56.

Identification

CAS Registry Number	67018-85-3
PubChem CID	104972
Molecular formula	C26H36N2O4
IUPAC name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile
UNII (FDA)	957Z3K3R56

Computed Descriptors

Molecular Weight	440.6
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	13
Exact Mass	440.26750763
Monoisotopic Mass	440.26750763
Topological Polar Surface Area	72.7
Heavy Atom Count	32
Formal Charge	0

Physical description & handling notes

• 207.3 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• Norverapamil has known human metabolites that include 5-Amino-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, 2-(3,4-dimethoxyphenyl)acetaldehyde, and D-715 (PR-22).
• Norverapamil is a known human metabolite of Verapamil.

Synonyms

Norverapamil; 67018-85-3; DTXSID80873799; 957Z3K3R56; 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile; alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile; D-591; N-demethylverapamil; 2-(3,4-dimethoxyphenyl)-5-(2-(3,4-dimethoxyphenyl)ethylamino)-2-propan-2-ylpentanenitrile; (2RS)-2-(3,4-Dimethoxyphenyl)-5-((2-(3,4-dimethoxy-phenyl)ethyl)amino)-2-(1-methylethyl)pentanenitrile; RefChem:854768; CHEBI:132050; DTXCID701012017; 266-544-8; Verapamil EP Impurity J; NORVERAPAMIL (6%)

Frequently Asked Questions

What are the CAS number and molecular formula of Norverapamil, Hydrochloride?

CAS 67018-85-3; molecular formula C26H36N2O4; molecular weight — g/mol.

What other names is Norverapamil, Hydrochloride known by?

Norverapamil, 67018-85-3, DTXSID80873799, 957Z3K3R56, 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile, alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile.

Is Norverapamil, Hydrochloride classified as hazardous?

Hazard statements reported: H301.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.