oxymetazoline

Description

oxymetazoline · CAS 1491-59-4 · C16H24N2O. UNII 8VLN5B44ZY. Melting Point: 182; Melting Point: 181-183 °C; Melting Point: 182 °C.

Identification

CAS Registry Number	1491-59-4
PubChem CID	4636
Molecular formula	C16H24N2O
IUPAC name	6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
UNII (FDA)	8VLN5B44ZY

Computed Descriptors

Molecular Weight	260.37
XLogP3	2.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	260.188863393
Monoisotopic Mass	260.188863393
Topological Polar Surface Area	44.6
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	182
Melting Point	181-183 °C
Melting Point	182 °C
Solubility	5.15e-02 g/L
LogP	3.4

Physical description & handling notes

• Solid
• Crystals from benzene
• ODORLESS; WHITE TO NEARLY WHITE, FINE, CRYSTALLINE POWDER; SOL IN ALC
• Mol wt 296.84. Crystals, dec 300-303 °C. Freely sol in water, alcohol. Practically insol in ether, chloroform, benzene /Hydrochloride/
• Insoluble in diethyl ether, chloroform, and benzene
• STABLE IN LIGHT & HEAT, & IS NONHYGROSCOPIC /HYDROCHLORIDE/

GHS Hazard Classification

Reported hazard statements	H300, H330 (96.6%), H318 (100%), H412 (100%)

Documented Uses

• THERAP CAT: Adrenergic (vasoconstrictor); nasal decongestant
• Oxymetazoline nasal spray is a potent /alpha 2/-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa.
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• From (4-tert-butyl-2,6-dimethyl-3-hydroxyphenyl)acetonitrile & ethylenediamine: FRUHSTORFER, MUELLER-CALGAN...CHEM ABST 57, 4674A (1962).
• 6-t-Butyl-2,4-dimethylphenol + formaldehyde + sodium cyanide + ethylenediamine (chloromethylation/cyanidation/condensation)

Synonyms

oxymetazoline; 1491-59-4; Oxymethazoline; Hazol; Oximetazolinum; Oxylazine; Rhinofrenol; Sinerol; Iliadin; Navisin; Nezeril; Nafrine; Oxymetozoline; Oximetazolina; Oxymetazolinum; Afrin

Frequently Asked Questions

What are the CAS number and molecular formula of oxymetazoline?

CAS 1491-59-4; molecular formula C16H24N2O; molecular weight — g/mol.

What other names is oxymetazoline known by?

oxymetazoline, 1491-59-4, Oxymethazoline, Hazol, Oximetazolinum, Oxylazine.

Is oxymetazoline classified as hazardous?

Hazard statements reported: H300, H330, H318, H412.

What are the key physical properties of oxymetazoline?

Melting Point: 182; Melting Point: 181-183 °C; Melting Point: 182 °C; Solubility: 5.15e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.