欧司哌米芬

Description

Ospemifene · CAS 128607-22-7 · C24H23ClO2. UNII B0P231ILBK.

Identification

CAS Registry Number	128607-22-7
PubChem CID	3036505
Molecular formula	C24H23ClO2
IUPAC name	2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
UNII (FDA)	B0P231ILBK

Computed Descriptors

Molecular Weight	378.9
XLogP3	6.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	378.1386577
Monoisotopic Mass	378.1386577
Topological Polar Surface Area	29.5
Heavy Atom Count	27
Formal Charge	0

Physical description & handling notes

• Crystals from ethanol + water
• White to off-white crystalline powder
• Insoluble
• Soluble in methanol
• Soluble in ethanol
• Chemical stability: Stable under recommended storage conditions.

GHS Hazard Classification

Reported hazard statements	H400 (88.9%), H410 (88.9%)

Documented Uses

• Preparation: R. J. Toivola et al., European Patent Office patent 95875 (1986 to Farmos).
• Ospemifene is indicated for the treatment of moderate to severe dyspareunia and vaginal dryness associated with menopause.
• Osphena is indicated for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. /Included in US product label/
• The pharmacokinetics of ospemifene has not been studied in women with severe hepatic impairment (Child-Pugh Class C); therefore, Osphena should not be used in women with severe hepatic impairment.
• For more Drug Warnings (Complete) data for Ospemifene (16 total), please visit the HSDB record page.
• Established Pharmacologic Class [EPC] - Estrogen Agonist/Antagonist

Synonyms

Ospemifene; 128607-22-7; Osphena; FC-1271a; senshio; Deamino-hydroxytoremifene; Fc-1271; Tore iii; 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol; 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol; Ospemifeno; (deaminohydroxy) toremifene; B0P231ILBK; CHEBI:73275; DTXSID101025426; Z-2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol

Frequently Asked Questions

What are the CAS number and molecular formula of Ospemifene?

CAS 128607-22-7; molecular formula C24H23ClO2; molecular weight — g/mol.

What other names is Ospemifene known by?

Ospemifene, 128607-22-7, Osphena, FC-1271a, senshio, Deamino-hydroxytoremifene.

Is Ospemifene classified as hazardous?

Hazard statements reported: H400, H410.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.