盐酸哌唑嗪

Description

prazosin hydrochloride · CAS 19237-84-4 · C19H22ClN5O4. UNII X0Z7454B90.

Identification

CAS Registry Number	19237-84-4
PubChem CID	68546
Molecular formula	C19H22ClN5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
UNII (FDA)	X0Z7454B90

Computed Descriptors

Molecular Weight	419.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	419.1360319
Monoisotopic Mass	419.1360319
Topological Polar Surface Area	107
Heavy Atom Count	29
Formal Charge	0
Complexity	544

Physical description & handling notes

• White to tan powder
• Crystals. MP: 278-280 °C /Prazosin/
• Soluble at ambient temperatures (mg/ml): acetone, 0.0072; methanol, 6.4; ethanol, 0.84; dimethylformamide, 1.3; dimethylacetamide, 1.2; chloroform, 0.041
• In water, 1.4 mg/ml @ pH approx 3.5
• 61.9 [ug/mL] (The mean of the results at pH 7.4)
• Prazosin hydrochloride capsules should be stored in well closed, light resistant containers at 15-30 °C.

GHS Hazard Classification

Reported hazard statements	H302 (56.6%), H315 (51.3%), H319 (51.3%), H335 (50%), H361 (92.1%), H373 (43.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Preparation: GB 1156973; Hess, US 3511836 (1969, 1970 both to Pfizer); Nl 7206067 (1972 to Brocades-Stheeman) ... . /Prazosin/
• Adrenergic alpha-Antagonists; Antihypertensive Agents; Sympatholytics
• Prazosin has been used with good results alone or in combination with a beta-adrenergic blocking agent for the preoperative management of the signs and symptoms of pheochromocytoma in a limited number of patients; however, these patients may be particularly susceptible to a marked hypotensive response to the initial dose of prazosin. Limited data also suggest that prazosin may be useful for the treatment of Raynaud's disease or phenomenon and ergotamine induced peripheral ischemia.
• Prazosin may be used as an adjunct to digoxin and diuretics for the treatment of congestive heart failure. However, prazosin has not been shown to improve survival in these patients. /NOT included in US product labeling/

Synonyms

Prazosin hydrochloride; 19237-84-4; Prazosin HCl; Peripress; Minipress Xl; Hypovase; Sinetens; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride; CP-12299-1; Prazosin clorhidrato; CP-12,299-1; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride; X0Z7454B90; 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline hydrochloride; Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-, monohydrochloride; DTXSID50172822

Frequently Asked Questions

What are the CAS number and molecular formula of prazosin hydrochloride?

CAS 19237-84-4; molecular formula C19H22ClN5O4; molecular weight — g/mol.

What other names is prazosin hydrochloride known by?

Prazosin hydrochloride, 19237-84-4, Prazosin HCl, Peripress, Minipress Xl, Hypovase.

Is prazosin hydrochloride classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.