Pamidronic acid

Description

Pamidronic acid · CAS 40391-99-9 · C3H11NO7P2. UNII OYY3447OMC. Melting Point: 254-262; Solubility: 1.58e+01 g/L; LogP: -4.7.

Identification

CAS Registry Number	40391-99-9
PubChem CID	4674
Molecular formula	C3H11NO7P2
IUPAC name	(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
UNII (FDA)	OYY3447OMC

Computed Descriptors

Molecular Weight	235.07
XLogP3	-6.9
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	235.00107569
Monoisotopic Mass	235.00107569
Topological Polar Surface Area	161
Heavy Atom Count	13
Formal Charge	0

Physical & Chemical Properties

Melting Point	254-262
Solubility	1.58e+01 g/L
LogP	-4.7

Physical description & handling notes

• Solid
• Pamidronic acid is a second generation, nitrogen containing bisphosphonate that inhibits osteoclast mediated bone loss It has a wide therapeutic index and a long duration of action as it can be given every 3-4 weeks for certain indications. Patients should be counselled regarding the risk of elevated blood urea nitrogen, renal tubular necrosis, and nephrotoxicity.

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Consumption (g per capita) in the USA (2002): 5.1e-05
• Pamidronate is in a class of drugs called bisphosphonates. Pamidronate reduces breakdown of the bones. Pamidronate is used in the treatment of Paget's disease of bone; to reduce high levels of calcium in the blood associated with malignancy (cancer); and to reduce the breakdown of bone due to metastases of breast cancer or multiple myeloma. For the treatment of moderate or severe hypercalcemia associated with malignancy
• Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.
• Pamidronate belongs to the drug class known as bisphosphonates, whose therapeutic value stems from their ability to inhibit osteoclast-mediated bone resorption.

Synonyms

PAMIDRONIC ACID; pamidronate; 40391-99-9; Amidronate; Acide pamidronique; (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; Acido pamidronico; Acidum pamidronicum; Ribodroat; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; DTXSID4023414; AHPrBP; OYY3447OMC; (3-Amino-1-hydroxypropylidene)diphosphonic acid; DTXCID003414; (3-amino-1-hydroxypropylidene)-1,1-biphosphonate

Frequently Asked Questions

What are the CAS number and molecular formula of Pamidronic acid?

CAS 40391-99-9; molecular formula C3H11NO7P2; molecular weight — g/mol.

What other names is Pamidronic acid known by?

PAMIDRONIC ACID, pamidronate, 40391-99-9, Amidronate, Acide pamidronique, (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid.

Is Pamidronic acid classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Pamidronic acid?

Melting Point: 254-262; Solubility: 1.58e+01 g/L; LogP: -4.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.