pyridostigmine bromide

Description

pyridostigmine bromide · CAS 101-26-8 · C9H13BrN2O2. UNII KVI301NA53. Melting Point: 152-154 °C.

Identification

CAS Registry Number	101-26-8
PubChem CID	7550
Molecular formula	C9H13BrN2O2
IUPAC name	(1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide
UNII (FDA)	KVI301NA53

Computed Descriptors

Molecular Weight	261.12
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	260.01604
Monoisotopic Mass	260.01604
Topological Polar Surface Area	33.4
Heavy Atom Count	14
Formal Charge	0
Complexity	182

Physical & Chemical Properties

Melting Point	152-154 °C

Physical description & handling notes

• WHITE OR PRACTICALLY WHITE, CRYSTALLINE POWDER
• AGREEABLE ODOR
• FREELY SOL IN WATER, ALCOHOL, PRACTICALLY INSOL IN ETHER, ACETONE, BENZENE
• FREELY SOL IN CHLOROFORM, SLIGHTLY SOL IN SOLVENT HEXANE
• 137.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• HYGROSCOPIC

GHS Hazard Classification

Reported hazard statements	H300 (72.6%), H301 (27.4%), H310 (66.1%), H317 (66.1%), H330 (67.7%), H331 (27.4%)

Documented Uses

• For the treatment of myasthenia gravis.
• URBAN, US PATENT NUMBER 2,572,579 (1951 TO HOFFMAN-LA ROCHE).
• 3-PYRIDINOL IS CONDENSED WITH DIMETHYLCARBAMOYL CHLORIDE IN THE PRESENCE OF A SUITABLE BASIC CATALYST SUCH AS DIMETHYLANILINE, MAGNESIUM OXIDE, ETC. THE RESULTING ESTER, 3-PYRIDYL DIMETHYLCARBAMATE, IS ISOLATED, DISSOLVED IN A SUITABLE ORGANIC SOLVENT, AND QUATERNIZED WITH METHYL BROMIDE.
• Breast Feeding; Lactation; Milk, Human; Cholinesterase Inhibitors; Parasympathomimetics
• Cholinesterase Inhibitors; Parasympathomimetics
• A QUATERNARY AMMONIUM ANTICHOLINESTERASE DRUG ...PRINCIPAL USE IS IN THE TREATMENT OF MYASTHENIA GRAVIS. ...

Synonyms

PYRIDOSTIGMINE BROMIDE; 101-26-8; Kalimin; Kalymin; Regonol; Regonal; Mestinon bromide; Pyridostigmini bromidum; Piridostigmina bromuro; DTXSID9023540; NSC-679759; NSC-758435; Ro 1-5130; KVI301NA53; 3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate; 3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide

Frequently Asked Questions

What are the CAS number and molecular formula of pyridostigmine bromide?

CAS 101-26-8; molecular formula C9H13BrN2O2; molecular weight — g/mol.

What other names is pyridostigmine bromide known by?

PYRIDOSTIGMINE BROMIDE, 101-26-8, Kalimin, Kalymin, Regonol, Regonal.

Is pyridostigmine bromide classified as hazardous?

Hazard statements reported: H300, H301, H310, H317, H330.

What are the key physical properties of pyridostigmine bromide?

Melting Point: 152-154 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.