Propiolactone

Description

Propiolactone · CAS 57-57-8 · C3H4O2. UNII 6RC3ZT4HB0. Boiling Point: 61 °C @ 20 MM HG; Boiling Point: 162 °C @760 [mm Hg]; Melting Point: -27 °F (EPA, 1998).

Identification

CAS Registry Number	57-57-8
PubChem CID	2365
Molecular formula	C3H4O2
IUPAC name	oxetan-2-one
UNII (FDA)	6RC3ZT4HB0

Computed Descriptors

Molecular Weight	72.06
XLogP3	-0.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	72.021129366
Monoisotopic Mass	72.021129366
Topological Polar Surface Area	26.3
Heavy Atom Count	5
Formal Charge	0

Physical & Chemical Properties

Boiling Point	61 °C @ 20 MM HG
Boiling Point	162 °C @760 [mm Hg]
Melting Point	-27 °F (EPA, 1998)
Melting Point	-33.4ºC
Melting Point	-33.4 °C
Melting Point	-28 °F
Flash Point	158 °F (EPA, 1998)
Flash Point	74 °C
Flash Point	165 °F (74 °C) (closed cup)
Flash Point	74 °C c.c.

Physical description & handling notes

• Beta-propiolactone appears as a colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments. (EPA, 1998)
• Colorless liquid with a slightly sweet odor; [NIOSH]
• COLOURLESS LIQUID WITH PUNGENT ODOUR.
• Colorless liquid with a slightly sweet odor.
• A COLORLESS LIQUID
• Colorless liquid.

Regulatory Status

Regulatory & Food Contact	FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS

GHS Hazard Classification

Reported hazard statements	H315, H319, H330, H350, H227, H301, H318, H335

Documented Uses

• beta-Propiolactone is used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk, and nutrient broth, and as a vapor-phase disinfectant in enclosed spaces. Its sporicidal action is used against vegetative bacteria, pathologic fungi, and viruses. beta-Propiolactone is also used as a chemical intermediate.
• Used as a sterilant in medicine for biological pharmaceuticals and surgical instruments; also used as a disinfectant and chemical intermediate; [ACGIH]
• Regulated as a carcinogen: See 29CFR1910.1013 (Code of Federal Regulations pertaining to the manufacturing, processing, repackaging, releasing, handling, and storing of this chemical).
• Using Disinfectants or Biocides [Category: Clean]
• Sterilizing Equipment [Category: Clean]
• VERSATILE INTERMEDIATE IN ORGANIC SYNTHESIS; DISINFECTANT

Synonyms

beta-propiolactone; Propiolactone; 2-Oxetanone; 57-57-8; Oxetan-2-one; Betaprone; Propanolide; 3-Propanolide; 1,3-Propiolactone; 3-Propiolactone; beta-Propionolactone; Propiolactona; 3-Hydroxypropionic acid lactone; Hydracrylic acid beta-lactone; beta-Propiolakton; Propiolactonum

Frequently Asked Questions

What are the CAS number and molecular formula of Propiolactone?

CAS 57-57-8; molecular formula C3H4O2; molecular weight — g/mol.

What other names is Propiolactone known by?

beta-propiolactone, Propiolactone, 2-Oxetanone, 57-57-8, Oxetan-2-one, Betaprone.

What is the regulatory status of Propiolactone?

Documented regulatory listings: FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS.

Is Propiolactone classified as hazardous?

Hazard statements reported: H315, H319, H330, H350, H227.

What are the key physical properties of Propiolactone?

Boiling Point: 61 °C @ 20 MM HG; Boiling Point: 162 °C @760 [mm Hg]; Melting Point: -27 °F (EPA, 1998); Melting Point: -33.4ºC.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.