Plecanatide

Description

Plecanatide · CAS 467426-54-6 · C65H104N18O26S4. UNII 7IK8Z952OK.

Identification

Computed Descriptors

Physical description & handling notes

• Amorphous, white to off-white powder
• Soluble in water
• 16 amino acid peptide
• Food Effect Subjects who received either a low-fat, low calorie (LF-LC) meal or a high fat, high calorie (HF-HC) meal reported looser stools than fasted subjects up to 24 hours after a single dose of 9 mg (3 times the recommended dose). In clinical studies, Plecanatide was administered with or without food.
• Oral: 30 mg tablets, Trulance

Documented Uses

• Guanylyl Cyclase C Agonists; Gastrointestinal Agents
• Plecanatide is indicated for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adult patients.
• Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Gastrointestinal Agents; Peptides; Guanylyl Cyclase C Agonists; Laxatives
• Trulance is indicated in adults for the treatment of: chronic idiopathic constipation (CIC); Irritable bowel syndrome with constipation (IBS-C). /Included in US product label/
• /BOXED WARNING/ WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS. Trulance is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile mice administration of a single oral dose of plecanatide caused deaths due to dehydration. Avoid use of Trulance in patients 6 years to less than 18 years of age. The safety and effectiveness of Trulance have not been established in patients less than 18 years of age.

Synonyms

PLECANATIDE; Trulance; 467426-54-6; Guanilib; plecanatida; 7IK8Z952OK; SP-304 (SYNERGY); DTXSID60196933; (3-Glutamic acid(D>E))human uroguanylin; [3-glutamic acid(D>E)]human uroguanylin; plecanatidum; RefChem:56535; Trulance Immediate release; A06AX07; DTXCID00119424; Plecanatide [USAN:INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Plecanatide?

CAS 467426-54-6; molecular formula C65H104N18O26S4; molecular weight — g/mol.

What other names is Plecanatide known by?

PLECANATIDE, Trulance, 467426-54-6, Guanilib, plecanatida, 7IK8Z952OK.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.