嘌呤霉素二盐酸盐

Description

Puromycin Dihydrochloride · CAS 58-58-2 · C22H29N7O5.2ClH. UNII PGN54228S5.

Identification

CAS Registry Number	58-58-2
PubChem CID	443311
Molecular formula	C22H29N7O5.2ClH
IUPAC name	(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
UNII (FDA)	PGN54228S5

Computed Descriptors

Molecular Weight	544.4
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	543.1763725
Monoisotopic Mass	543.1763725
Topological Polar Surface Area	161
Heavy Atom Count	36
Formal Charge	0
Complexity	680

Physical description & handling notes

• Puromycin dihydrochloride is a white powder. (NTP, 1992)
• Soluble (NTP, 1992)
• 204.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Antimetabolites that are useful in cancer chemotherapy.
• Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
• Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Synonyms

Puromycin dihydrochloride; 58-58-2; Puromycin hydrochloride; DTXSID7045861; P-638 DIHYDROCHLORIDE; CL 16,536; PGN54228S5; CL-13900 DIHYDROCHLORIDE; NSC-3055; CL-16536; DTXCID5025861; Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, dihydrochloride, (S)-; Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, dihydrochloride, L-; RefChem:177306; 200-387-8; Puromycin 2HCl

Frequently Asked Questions

What are the CAS number and molecular formula of Puromycin Dihydrochloride?

CAS 58-58-2; molecular formula C22H29N7O5.2ClH; molecular weight — g/mol.

What other names is Puromycin Dihydrochloride known by?

Puromycin dihydrochloride, 58-58-2, Puromycin hydrochloride, DTXSID7045861, P-638 DIHYDROCHLORIDE, CL 16,536.

Is Puromycin Dihydrochloride classified as hazardous?

Hazard statements reported: H302.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.