盐酸普托品

Description

protopine hydrochloride · CAS 6164-47-2 · C20H20ClNO5. UNII 96481YJ70G.

Identification

CAS Registry Number	6164-47-2
PubChem CID	22543
Molecular formula	C20H20ClNO5
IUPAC name	15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one;hydrochloride
UNII (FDA)	96481YJ70G

Computed Descriptors

Molecular Weight	389.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	389.1030004
Monoisotopic Mass	389.1030004
Topological Polar Surface Area	57.2
Heavy Atom Count	27
Formal Charge	0
Complexity	542

Physical description & handling notes

• Solid; [Merck Index]
• PRISMS FROM ALC
• SOL IN 143 PARTS WATER @ 13 °C, SOL IN ALC

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• Protopine: Found in opium and many herbs; [Merck Index]
• Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
• Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
• CACL2 (0.2 G/KG, IV) INDUCED FIBRILLATION OF THE RAT CARDIAC VENTRICLES FOR 2 SEC AND CAUSED DEATH OF THE ANIMALS. PROTOPINE-HCL (10 MG/KG) PROLONGED THE VENTRICULAR FIBRILLATION TO 186 SEC. IT ALSO RESTORED THE SINUS RHYTHM 3 MIN AFTER ITS ADMIN IN ALL TREATED ANIMALS.

Synonyms

PROTOPINE HYDROCHLORIDE; 6164-47-2; Protopine HCl; NSC-11440; 96481YJ70G; 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride; Bis(1,3)benzodioxolo(4,5-C:5',6'-g)azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-, hydrochloride; DTXSID70210654; BIS(1,3)BENZODIOXOLO(4,5-C:5',6'-G)AZECIN-13(5H)-ONE, 4,6,7,14-TETRAHYDRO-5-METHYL-, HYDROCHLORIDE (1:1); RefChem:176687; DTXCID00133145; 228-196-5; Protopine (hydrochloride); NSC11440; HSDB 3556; EINECS 228-196-5

Frequently Asked Questions

What are the CAS number and molecular formula of protopine hydrochloride?

CAS 6164-47-2; molecular formula C20H20ClNO5; molecular weight — g/mol.

What other names is protopine hydrochloride known by?

PROTOPINE HYDROCHLORIDE, 6164-47-2, Protopine HCl, NSC-11440, 96481YJ70G, 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride.

Is protopine hydrochloride classified as hazardous?

Hazard statements reported: H301.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.