利塞膦酸

Description

Risedronic acid · CAS 105462-24-6 · C7H11NO7P2. UNII KM2Z91756Z. Boiling Point: 692.3; Melting Point: 252-262; Solubility: 1.04e+01 g/L.

Identification

CAS Registry Number	105462-24-6
PubChem CID	5245
Molecular formula	C7H11NO7P2
IUPAC name	(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid
UNII (FDA)	KM2Z91756Z

Computed Descriptors

Molecular Weight	283.11
XLogP3	-3.1
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	283.00107569
Monoisotopic Mass	283.00107569
Topological Polar Surface Area	148
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Boiling Point	692.3
Melting Point	252-262
Solubility	1.04e+01 g/L
LogP	-3.6

Physical description & handling notes

• Solid
• Miscible in water. /Estimated/
• 2.1X10-11 mm Hg at 25 °C /Estimated/
• log Kow = -0.29 /Estimated/
• Henry's Law constant = 1.0X10-29 atm-cu m/mol at 25 °C /Estimated/
• pKa1 = 2.9 phosphoric acid moiety based on etidronic acid; pKa2= 7 phosphoric acid moiety based on etidronic acid /Etidronic acid/

GHS Hazard Classification

Reported hazard statements	H290 (50%), H302 (33.3%), H314 (66.7%), H315 (33.3%), H319 (33.3%), H335 (66.7%), H361 (50%), H362 (16.7%)

Documented Uses

• MEDICATION: Bone resorption inhibitor.
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in the USA (2002): 0.00196
• For the treatment of Paget's disease of the bone (osteitis deformans), postmenopausal and glucocorticoid-induced osteoporosis
• Preparation: J.J. Benedict, C. M. Perkins, EP 186405; eidem US 5583122 (1986, 1996 both to Proctor and Gamble)

Synonyms

Risedronic acid; Risedronate; 105462-24-6; Acido risedronico; Acide risedronique; Ridron; Acidum risedronicum; Phosphonic acid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis-; [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid; M05BA07; KM2Z91756Z; Phosphonic acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-; DTXSID2023563; 2-(3-pyridinyl)-1-hydroxyethane diphosphonic acid; (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonic acid; RefChem:56783

Frequently Asked Questions

What are the CAS number and molecular formula of Risedronic acid?

CAS 105462-24-6; molecular formula C7H11NO7P2; molecular weight — g/mol.

What other names is Risedronic acid known by?

Risedronic acid, Risedronate, 105462-24-6, Acido risedronico, Acide risedronique, Ridron.

Is Risedronic acid classified as hazardous?

Hazard statements reported: H290, H302, H314, H315, H319.

What are the key physical properties of Risedronic acid?

Boiling Point: 692.3; Melting Point: 252-262; Solubility: 1.04e+01 g/L; LogP: -3.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.