Spironolactone

Description

Spironolactone · CAS 52-01-7 · C24H32O4S. UNII 27O7W4T232. Boiling Point: 134 °C; Melting Point: 198-207; Melting Point: 134-135 °C.

Identification

CAS Registry Number	52-01-7
PubChem CID	5833
Molecular formula	C24H32O4S
IUPAC name	S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
UNII (FDA)	27O7W4T232

Computed Descriptors

Molecular Weight	416.6
XLogP3	2.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	416.20213067
Monoisotopic Mass	416.20213067
Topological Polar Surface Area	85.7
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Boiling Point	134 °C
Melting Point	198-207
Melting Point	134-135 °C
Melting Point	134.5 °C
Solubility	In water, 22 mg/L at 25 °C
Solubility	1.98e-03 g/L
LogP	2.78
LogP	log Kow = 2.78
LogP	3.4

Physical description & handling notes

• Solid
• Crystals from methanol
• Light cream-colored to light tan, crystalline powder
• Mild mercaptan-like odor
• Soluble in most organic solvents
• Soluble in ethyl acetate and ethanol; slightly soluble in methanol

Regulatory Status

GHS notification summary	0.6% (1 / 174)

GHS Hazard Classification

GHS notification summary	0.6% (1 / 174)
Reported hazard statements	H302 (35.6%), H312 (31%), H332 (31%), H351 (66.1%), H360 (52.9%), H373 (25.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >7500
• Consumption (g per capita; approx.) in Germany (2009): 0.0916
• Consumption (g per capita) in the USA (2002): 0.0436
• Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Cosmetics product ingredient: Spironolactone

Synonyms

spironolactone; 52-01-7; Aldactone; Verospirone; Spirolactone; Spiresis; Uractone; Xenalon; spironolattone; Espironolactona; Spironolactonum; Abbolactone; Diatensec; Laractone; SC 9420; SC-9420

Frequently Asked Questions

What are the CAS number and molecular formula of Spironolactone?

CAS 52-01-7; molecular formula C24H32O4S; molecular weight — g/mol.

What other names is Spironolactone known by?

spironolactone, 52-01-7, Aldactone, Verospirone, Spirolactone, Spiresis.

Is Spironolactone classified as hazardous?

0.6% of GHS notifications report no hazard classification (1 of 174).

What are the key physical properties of Spironolactone?

Boiling Point: 134 °C; Melting Point: 198-207; Melting Point: 134-135 °C; Melting Point: 134.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.