金硫苹果酸钠

Description

Sodium Aurothiomalate · CAS 12244-57-4 · C4H3AuNa2O4S. UNII E4768ZY6GM.

Identification

CAS Registry Number	12244-57-4
PubChem CID	22318
Molecular formula	C4H3AuNa2O4S
IUPAC name	disodium;gold(1+);2-sulfidobutanedioate
UNII (FDA)	E4768ZY6GM

Computed Descriptors

Molecular Weight	390.08
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	389.921313
Monoisotopic Mass	389.921313
Topological Polar Surface Area	81.3
Heavy Atom Count	12
Formal Charge	0
Complexity	126

Physical description & handling notes

• White to yellowish-white powder; mixture of mono- and disodium salts
• Odorless
• Metallic taste
• Very soluble in water; practically insoluble in alcohol, ether
• Following the date of manufacture, ... gold sodium thiomalate injection /has an expiration date/ of 5 years.
• Aqueous solutions are colorless to pale yellow; pH of 5% aq solution: 5.8-6.5

GHS Hazard Classification

Reported hazard statements	H302 (100%), H317 (100%), H332 (100%)

Documented Uses

• ... A solution of thiomalic acid and 3 equivalents of sodium hydroxide are mixed with an aqueous suspension of gold(I)iodide. The product, a mixture of the mono- and disodium salts, is precipitated by the addition of ethanol.
• A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
• Breast Feeding; Lactation; Milk, Human; Antirheumatic Agents
• ... Gold sodium thiomalate ... /is/ indicated in the treatment of adult or juvenile rheumatoid arthritis. ... /This agent is/ usually used for treating patients who show evidence of continued or additional disease activity despite conservative therapy, e.g., with salicylates (especially aspirin) or other nonsteroidal anti-inflammatory agents, glucocorticoids, etc. /Included in US product labeling/
• Gold compounds are used in the treatment of these rheumatic conditions / psoriatic arthritis, Felty's syndrome/. /Gold compounds; NOT included in US product labeling/
• Patients with an impaired sulfoxidation ability (decreased ability to oxidize sulfhydryl-containing compounds) may be predisposed to ... /gold sodium thiomalate/ toxicity.

Synonyms

Sodium aurothiomalate; Tauredon; GOLD SODIUM THIOMALATE; Chrysothios; 12244-57-4; Myocrisin; Kidon; Myochrysine; Aurothiomalate sodium; Natrii aurothiomalas; Aurothiomalate de sodium; Aurothiomalate Disodium; Aurolate; Butanedioic acid, mercapto-, monogold(1+) sodium salt; E4768ZY6GM; disodium 2-(auriosulfanyl)butanedioate

Frequently Asked Questions

What are the CAS number and molecular formula of Sodium Aurothiomalate?

CAS 12244-57-4; molecular formula C4H3AuNa2O4S; molecular weight — g/mol.

What other names is Sodium Aurothiomalate known by?

Sodium aurothiomalate, Tauredon, GOLD SODIUM THIOMALATE, Chrysothios, 12244-57-4, Myocrisin.

Is Sodium Aurothiomalate classified as hazardous?

Hazard statements reported: H302, H317, H332.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.