sulfamethizole

Description

sulfamethizole · CAS 144-82-1 · C9H10N4O2S2. UNII 25W8454H16. Melting Point: 406 °F (NTP, 1992); Melting Point: 208; Melting Point: 210 °C.

Identification

CAS Registry Number	144-82-1
PubChem CID	5328
Molecular formula	C9H10N4O2S2
IUPAC name	4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
UNII (FDA)	25W8454H16

Computed Descriptors

Molecular Weight	270.3
XLogP3	0.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	270.02451792
Monoisotopic Mass	270.02451792
Topological Polar Surface Area	135
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	406 °F (NTP, 1992)
Melting Point	208
Melting Point	210 °C
Melting Point	208 °C
Solubility	1050
Solubility	In water, 105 mg/L at 37 °C
Solubility	6.11e-01 g/L
LogP	0.54
LogP	log Kow = 0.54
LogP	0.9

Physical description & handling notes

• Sulfamethizole is a white powder. (NTP, 1992)
• Solid
• Crystals from water
• Colorless crystal
• Insoluble at pH 6.5 (=10mg/ml). (NTP, 1992)
• 1 g dissolves in: 4000 mL water at pH 6.5, 5 mL water at pH 7.5, 40 g methanol, 30 g ethanol, 10 g acetone, 1370 g ether, 2800 g chloroform; practically insol in benzene

GHS Hazard Classification

Reported hazard statements	H317 (98.8%)

Documented Uses

• THERAP CAT (VET): Antibacterial
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Prepared by the reaction of acetaldehyde thiosemicarbazone with p-acetylaminobenzenesulfonyl chloride in pyridine.
• Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-: ACTIVE
• For the treatment of urinary tract infection

Synonyms

sulfamethizole; 144-82-1; Sulfamethizol; Sulphamethizole; Thiosulfil; 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; Rufol; Sulfamethylthiadiazole; Sulfurine; Urosulfin; Methazol; Microsul; Proklar; Sulfametizol; Ayerlucil; Sulfapyelon

Frequently Asked Questions

What are the CAS number and molecular formula of sulfamethizole?

CAS 144-82-1; molecular formula C9H10N4O2S2; molecular weight — g/mol.

What other names is sulfamethizole known by?

sulfamethizole, 144-82-1, Sulfamethizol, Sulphamethizole, Thiosulfil, 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide.

Is sulfamethizole classified as hazardous?

Hazard statements reported: H317.

What are the key physical properties of sulfamethizole?

Melting Point: 406 °F (NTP, 1992); Melting Point: 208; Melting Point: 210 °C; Melting Point: 208 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.