topiramate

Description

topiramate · CAS 97240-79-4 · C12H21NO8S. UNII 0H73WJJ391. Boiling Point: 438.7; Melting Point: 123-125 ºC; Melting Point: 125-126 °C.

Identification

CAS Registry Number	97240-79-4
PubChem CID	5284627
Molecular formula	C12H21NO8S
IUPAC name	[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate
UNII (FDA)	0H73WJJ391

Computed Descriptors

Molecular Weight	339.36
XLogP3	-0.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	339.09878780
Monoisotopic Mass	339.09878780
Topological Polar Surface Area	124
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Boiling Point	438.7
Melting Point	123-125 ºC
Melting Point	125-126 °C
Melting Point	125 - 126 °C
Solubility	9.8
LogP	0.13
LogP	0.53
Dissociation Constants	8.7

Physical description & handling notes

• Solid
• Crystals from ethyl acetate and benzene
• White crystalline powder
• Bitter
• Soluble in most alkaline solutions containing sodium hydroxide or sodium phosphate and having a pH of 9 to 10. It is freely soluble in acetone, chloroform, dimethylsulfoxide, and ethanol.
• In water, 9,800 mg/L, temp not specified

GHS Hazard Classification

Reported hazard statements	H315 (85.1%), H319 (86%), H335 (85.1%), H361 (14.9%), H351, H360, H371, H372

Documented Uses

• Use (kg) in Switzerland (2009): >250
• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita) in Switzerland (2009): 0.032
• Consumption (g per capita; approx.) in Germany (2009): 0.012
• Consumption (g per capita) in the USA (2002): 0.035
• D-Fructose is reacted with acetone to produce the bisacetonide. This compound is then condensed with sulfamoyl chloride in presence of sodium hydride.

Synonyms

topiramate; 97240-79-4; Topamax; Epitomax; Topamax Sprinkle; Topina; Tipiramate; Topiramato; Topiramatum; Epitoma; Topimax; Topomax; McN-4853; Tipiramato; Topamac; RWJ-17021

Frequently Asked Questions

What are the CAS number and molecular formula of topiramate?

CAS 97240-79-4; molecular formula C12H21NO8S; molecular weight — g/mol.

What other names is topiramate known by?

topiramate, 97240-79-4, Topamax, Epitomax, Topamax Sprinkle, Topina.

Is topiramate classified as hazardous?

Hazard statements reported: H315, H319, H335, H361, H351.

What are the key physical properties of topiramate?

Boiling Point: 438.7; Melting Point: 123-125 ºC; Melting Point: 125-126 °C; Melting Point: 125 - 126 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.