Tolbutamide

Description

Tolbutamide · CAS 64-77-7 · C12H18N2O3S. UNII 982XCM1FOI. Melting Point: 262 to 264 °F (NTP, 1992); Melting Point: 128.5; Melting Point: 128.5-129.5 °C.

Identification

CAS Registry Number	64-77-7
PubChem CID	5505
Molecular formula	C12H18N2O3S
IUPAC name	1-butyl-3-(4-methylphenyl)sulfonylurea
UNII (FDA)	982XCM1FOI

Computed Descriptors

Molecular Weight	270.35
XLogP3	2.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	270.10381361
Monoisotopic Mass	270.10381361
Topological Polar Surface Area	83.7
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	262 to 264 °F (NTP, 1992)
Melting Point	128.5
Melting Point	128.5-129.5 °C
Melting Point	128.5 °C
Solubility	109
Solubility	In water, 109 mg/l @ 37 °C
Solubility	2.02e-01 g/L
Density	1.245 g/cu cm @ 25 °C
LogP	2.34
LogP	log Kow= 2.34

Physical description & handling notes

• Tolbutamide appears as white crystals. (NTP, 1992)
• Solid
• WHITE OR PRACTICALLY WHITE CRYSTALLINE POWDER
• Crystals
• MP: 41-43 °C; when anhyd, mp range is 130-133 °C /Sodium salt tetrahydrate/
• less than 1 mg/mL at 61 °F (NTP, 1992)

GHS Hazard Classification

Reported hazard statements	H302 (28.6%), H317 (57.1%), H361 (14.3%), H370 (14.3%)

Documented Uses

• Therap cat (Vet): Hypoglycemic agent
• An orally effective hypoglycemic drug.
• FROM BUTYL ISOCYANATE & 4-TOLUENESULFONAMIDE SODIUM...
• British patent 808,071 and Aumuller, Herr, German patent 1,066,575 (both 1959 to Hoechst); Ruschig et al, US patent 2,968,158 (1961 to Upjohn).
• Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-: ACTIVE
• For treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.

Synonyms

tolbutamide; 64-77-7; Diabetamid; Arkozal; Butamide; Willbutamide; Artosin; Ipoglicone; Rastinon; 1-Butyl-3-(p-tolylsulfonyl)urea; 1-Butyl-3-tosylurea; Diabetol; Diabuton; Glyconon; Tolbutamid; Aglicid

Frequently Asked Questions

What are the CAS number and molecular formula of Tolbutamide?

CAS 64-77-7; molecular formula C12H18N2O3S; molecular weight — g/mol.

What other names is Tolbutamide known by?

tolbutamide, 64-77-7, Diabetamid, Arkozal, Butamide, Willbutamide.

Is Tolbutamide classified as hazardous?

Hazard statements reported: H302, H317, H361, H370.

What are the key physical properties of Tolbutamide?

Melting Point: 262 to 264 °F (NTP, 1992); Melting Point: 128.5; Melting Point: 128.5-129.5 °C; Melting Point: 128.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.