Trilostane

Description

Trilostane · CAS 13647-35-3 · C20H27NO3. UNII L0FPV48Q5R. Melting Point: 264; Melting Point: 264 °C; Solubility: 5.93e-02 g/L.

Identification

CAS Registry Number	13647-35-3
PubChem CID	656583
Molecular formula	C20H27NO3
IUPAC name	(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile
UNII (FDA)	L0FPV48Q5R

Computed Descriptors

Molecular Weight	329.4
XLogP3	2.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	329.19909372
Monoisotopic Mass	329.19909372
Topological Polar Surface Area	76.8
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	264
Melting Point	264 °C
Solubility	5.93e-02 g/L

Physical description & handling notes

• Solid
• 186.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID9023706]
• 174.52 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 166.68 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 173.45 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H315 (98%), H319 (98%), H361 (100%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
• Steroidal compounds with abortifacient activity.
• Substances that inhibit or prevent the proliferation of NEOPLASMS.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
• H - Systemic hormonal preparations, excl. sex hormones and insulins

Synonyms

Trilostane; 13647-35-3; Modrenal; Desopan; Vetoryl; Modrastane; Trilostano; Win-24540; Trilostanum; DTXSID9023706; WIN 24,540; L0FPV48Q5R; Win 24540; CHEBI:32260; NSC-758904; DTXCID103706

Frequently Asked Questions

What are the CAS number and molecular formula of Trilostane?

CAS 13647-35-3; molecular formula C20H27NO3; molecular weight — g/mol.

What other names is Trilostane known by?

Trilostane, 13647-35-3, Modrenal, Desopan, Vetoryl, Modrastane.

Is Trilostane classified as hazardous?

Hazard statements reported: H315, H319, H361.

What are the key physical properties of Trilostane?

Melting Point: 264; Melting Point: 264 °C; Solubility: 5.93e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.