Temsirolimus

Description

Temsirolimus · CAS 162635-04-3 · C56H87NO16. UNII 624KN6GM2T. Solubility: 2.35e-03 g/L.

Identification

CAS Registry Number	162635-04-3
PubChem CID	6918289
Molecular formula	C56H87NO16
UNII (FDA)	624KN6GM2T

Computed Descriptors

Molecular Weight	1030.3
XLogP3	5.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	11
Exact Mass	1029.60248569
Monoisotopic Mass	1029.60248569
Topological Polar Surface Area	242
Heavy Atom Count	73
Formal Charge	0

Physical & Chemical Properties

Solubility	2.35e-03 g/L

Physical description & handling notes

• Solid
• White to off-white powder
• White solid
• Practically insoluble in water; soluble in alcohol
• Solubility is independent of pH
• Soluble in water

GHS Hazard Classification

Reported hazard statements	H360 (50.8%), H410 (95.1%)

Documented Uses

• Preparation: J. S. Skotnicki et al., US 5362718 (1994 to Am. Home Prod.)
• For the treatment of renal cell carcinoma (RCC). Also investigated for use/treatment in breast cancer, lymphoma (unspecified), rheumatoid arthritis, and multiple myeloma.
• Temsirolimus is an inhibitor of cell proliferation and anticancer agent that is used as treatment of advanced renal cell cancer. Temsirolimus therapy is frequently associated with mild serum enzyme elevations, but has yet to be linked to instances of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Immunosuppressive Agents
• Antineoplastic Agents; Transplant Drugs
• Temsirolimus is approved to treat:

Synonyms

Temsirolimus; CCI-779; 162635-04-3; Torisel; 624KN6GM2T; DTXSID2040945; DTXCID0020945; Rapamycin 42-(2,2-bis(hydroxymethyl)propionate); Rapamycin, 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate); temsirolimusum; L01XE09; Temsirolimus Injection; RefChem:56883; MFCD00934421; CHEMBL1201182; NCGC00167518-01

Frequently Asked Questions

What are the CAS number and molecular formula of Temsirolimus?

CAS 162635-04-3; molecular formula C56H87NO16; molecular weight — g/mol.

What other names is Temsirolimus known by?

Temsirolimus, CCI-779, 162635-04-3, Torisel, 624KN6GM2T, DTXSID2040945.

Is Temsirolimus classified as hazardous?

Hazard statements reported: H360, H410.

What are the key physical properties of Temsirolimus?

Solubility: 2.35e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.