Terbutaline

Description

Terbutaline · CAS 23031-25-6 · C12H19NO3. UNII N8ONU3L3PG. Melting Point: 247; Melting Point: 119 - 122 °C; Solubility: 5.84e+00 g/L.

Identification

CAS Registry Number	23031-25-6
PubChem CID	5403
Molecular formula	C12H19NO3
IUPAC name	5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
UNII (FDA)	N8ONU3L3PG

Computed Descriptors

Molecular Weight	225.28
XLogP3	0.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	225.13649347
Monoisotopic Mass	225.13649347
Topological Polar Surface Area	72.7
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	247
Melting Point	119 - 122 °C
Solubility	5.84e+00 g/L
LogP	0.9
LogP	1.4
LogP	0.08
Dissociation Constants	8.65
Dissociation Constants	8.7
Collision Cross Section	155.27 Ų [M+H]+
Collision Cross Section	166.43 Ų [M+Na]+

Physical description & handling notes

• Solid
• 155.28 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 149.28 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 154.9 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• Terbutaline is a beta-2 adrenergic receptor agonist indicated to treat reversibly bronchospasm in asthmatic patients with bronchitis and emphysema. It has a short duration as the inhaled form is taken up to three times daily, and the therapeutic window is wide.

GHS Hazard Classification

Reported hazard statements	H361 (100%), H373 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• Consumption (g per capita) in France (2004): 0.00273
• Terbutaline is indicated for prevention and reversal of bronchospasm in patients at least 12 years old, with asthma and reversible bronchospasm associated with bronchitis and emphysema.
• Breast Feeding; Lactation; Milk, Human; Bronchodilator Agents; Beta Adrenergic Agonists
• Antiasthmatic and medicines for chronic obstructive pulmonary disease

Synonyms

terbutaline; 23031-25-6; Terbutalin; Terbutalina; Terbutalinum; 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol; Asthmasian; 5-(2-(tert-Butylamino)-1-hydroxyethyl)benzene-1,3-diol; 1,3-Benzenediol, 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-; N8ONU3L3PG; 5-(2-((1,1-DIMETHYLETHYL)AMINO)-1-HYDROXYETHYL)-1,3-BENZENEDIOL; CHEBI:9449; DTXSID7021310; 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-; 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol; Butalitab

Frequently Asked Questions

What are the CAS number and molecular formula of Terbutaline?

CAS 23031-25-6; molecular formula C12H19NO3; molecular weight — g/mol.

What other names is Terbutaline known by?

terbutaline, 23031-25-6, Terbutalin, Terbutalina, Terbutalinum, 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol.

Is Terbutaline classified as hazardous?

Hazard statements reported: H361, H373.

What are the key physical properties of Terbutaline?

Melting Point: 247; Melting Point: 119 - 122 °C; Solubility: 5.84e+00 g/L; LogP: 0.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.