Varenicline tartrate

Description

Varenicline tartrate · CAS 375815-87-5 · C13H13N3. UNII W6HS99O8ZO. Solubility: 8.77e-02 g/L; LogP: 0.9.

Identification

CAS Registry Number	375815-87-5
PubChem CID	5310966
Molecular formula	C13H13N3
IUPAC name	(1S,12R)-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
UNII (FDA)	W6HS99O8ZO

Computed Descriptors

Molecular Weight	211.26
XLogP3	0.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	211.110947427
Monoisotopic Mass	211.110947427
Topological Polar Surface Area	37.8
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Solubility	8.77e-02 g/L
LogP	0.9

Physical description & handling notes

• Solid
• Stable under recommended storage conditions.
• Hazardous decomposition products: Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx)
• 151 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• White to off-white to slightly yellow solid; highly soluble in water /Verencline tartrate/
• Varenicline is a partial nicotinic acetylcholine receptor agonist, designed to partially activate this system while displacing nicotine at its sites of action in the brain.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H400 (100%), H410

Documented Uses

• For use as an aid in smoking cessation (A308).
• Preparation: P. R. P. Brooks, J. W. Coe, World Intellectual Property Organization patent 0162736 (2001 to Pfizer).
• Chantix tablets contain the active ingredient varenicline (as the tartrate salt)
• For use as an aid in smoking cessation. Varenicline as a nasal spray is indicated for the symptomatic treatment of dry eye disease.
• Varenicline is a partial agonist of the nicotinic acetylcholine receptor and is used to help in smoking cessation. Varenicline has been associated with a low rate of serum enzyme elevations during therapy and, since approval and its widescale use, with rare instances of clinically apparent mild liver injury.
• Breast Feeding; Lactation; Milk, Human; Nicotinic Agonists

Synonyms

Varenicline; vareniclina; vareniclinum; CP 526555; CP-526,555; W6HS99O8ZO; CP-526555; CHEBI:84500; 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine; (1R,12S)-5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2(11),3,5,7,9-pentaene; 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine; DTXSID40861516; DTXSID70891447; (1R,12S)-5,8,14-triazatetracyclo(10.3.1.0^(2,11).0^(4,9))hexadeca-2(11),3,5,7,9-pentaene; RefChem:58779; 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)benzazepine

Frequently Asked Questions

What are the CAS number and molecular formula of Varenicline tartrate?

CAS 375815-87-5; molecular formula C13H13N3; molecular weight — g/mol.

What other names is Varenicline tartrate known by?

Varenicline, vareniclina, vareniclinum, CP 526555, CP-526,555, W6HS99O8ZO.

Is Varenicline tartrate classified as hazardous?

Hazard statements reported: H302, H400, H410.

What are the key physical properties of Varenicline tartrate?

Solubility: 8.77e-02 g/L; LogP: 0.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.