维帕他韦中间体A13

Description

Velpatasvir intermediate A13 · CAS 1377049-84-7 · C49H54N8O8. UNII KCU0C7RS7Z.

Identification

CAS Registry Number	1377049-84-7
PubChem CID	67683363
Molecular formula	C49H54N8O8
UNII (FDA)	KCU0C7RS7Z

Computed Descriptors

Molecular Weight	883.0
XLogP3	6.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	13
Exact Mass	882.40646071
Monoisotopic Mass	882.40646071
Topological Polar Surface Area	193
Heavy Atom Count	65
Formal Charge	0

Physical description & handling notes

• Velpatasvir is a small molecule direct-acting antiviral used in the treatment of hepatitis C in combination with sofosbuvir. Velpatasvir prevents viral replication by inhibiting non-structural protein 5A (NS5A). At a dose 5 times the recommended dose, velpatasvir does not prolong QTc interval to any clinically relevant extent.

Regulatory Status

GHS notification summary	50% (1 / 2)

GHS Hazard Classification

GHS notification summary	50% (1 / 2)
Reported hazard statements	H413 (50%), H410 (100%)

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Antiviral Agents; NS5A Inhibitors
• Take with or without food. Multiple different combination products contain velpatasvir. Take Epclusa with or without food. Take Vosevi with food.
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
• Established Pharmacologic Class [EPC] - Hepatitis C Virus NS5A Inhibitor
• Mechanisms of Action [MoA] - Breast Cancer Resistance Protein Inhibitors
• Mechanisms of Action [MoA] - P-Glycoprotein Inhibitors

Synonyms

Velpatasvir; 1377049-84-7; GS-5816; GS5816; KCU0C7RS7Z; GS 5816; CHEBI:133009; DTXSID70722565; EPCLUSA COMPONENT VELPATASVIR; velpatasvirum; RefChem:901782; DTXCID401513466; MFCD28411371; Velpatasvir R Isomer (Imidazole); UNII-KCU0C7RS7Z; Velpatasvir [USAN:INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Velpatasvir intermediate A13?

CAS 1377049-84-7; molecular formula C49H54N8O8; molecular weight — g/mol.

What other names is Velpatasvir intermediate A13 known by?

Velpatasvir, 1377049-84-7, GS-5816, GS5816, KCU0C7RS7Z, GS 5816.

Is Velpatasvir intermediate A13 classified as hazardous?

50% of GHS notifications report no hazard classification (1 of 2).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.