3,5-二甲基-1-氨基金刚烷

Description

3,5-Dimethyl-1-aminoadamantane · CAS 19982-08-2 · C12H21N. UNII W8O17SJF3T. Boiling Point: 239.8; Melting Point: 153; Solubility: 4.55e-02 g/L.

Identification

CAS Registry Number	19982-08-2
PubChem CID	4054
Molecular formula	C12H21N
IUPAC name	3,5-dimethyladamantan-1-amine
UNII (FDA)	W8O17SJF3T

Computed Descriptors

Molecular Weight	179.30
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	179.167399674
Monoisotopic Mass	179.167399674
Topological Polar Surface Area	26
Heavy Atom Count	13
Formal Charge	0

Physical & Chemical Properties

Boiling Point	239.8
Melting Point	153
Solubility	4.55e-02 g/L
LogP	3.28
LogP	log Kow = 3.28
LogP	3.5
Dissociation Constants	10.27

Physical description & handling notes

• Solid
• Oil
• White to off white fine powder. Crystals from alcohol/ether. MP: 290-295 °C, also reported as 290-295 °C. Soluble in water. /Memantine hydrochloride/
• 258 °C (hydrochloride salt)
• soluble in water
• Stable under recommended storage conditions.

Regulatory Status

GHS notification summary	50% (1 / 2)

GHS Hazard Classification

GHS notification summary	50% (1 / 2)
Reported hazard statements	H302 (50%)

Documented Uses

• Antiparkinson Agents; Dopamine Agents; Excitatory Amino Acid Antagonists
• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• For the treatment of moderate to severe dementia of the Alzheimer's type.
• /Preparation/ of the free base and hydrochloride: J. Mills, E. Krumkalns, USA 3391142 (1968 to Lilly).
• NMDA-receptor antagonist; derivative of adamantane.

Synonyms

memantine; 19982-08-2; 3,5-dimethyladamantan-1-amine; 1-Amino-3,5-dimethyladamantane; Memantina; 3,5-Dimethyl-1-adamantanamine; Memantinum; 1,3-Dimethyl-5-adamantanamine; nemdatine; 3,5-Dimethyl-1-aminoadamantane; Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-; DTXSID5045174; DRG-0267; 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine; W8O17SJF3T; D-145

Frequently Asked Questions

What are the CAS number and molecular formula of 3,5-Dimethyl-1-aminoadamantane?

CAS 19982-08-2; molecular formula C12H21N; molecular weight — g/mol.

What other names is 3,5-Dimethyl-1-aminoadamantane known by?

memantine, 19982-08-2, 3,5-dimethyladamantan-1-amine, 1-Amino-3,5-dimethyladamantane, Memantina, 3,5-Dimethyl-1-adamantanamine.

Is 3,5-Dimethyl-1-aminoadamantane classified as hazardous?

50% of GHS notifications report no hazard classification (1 of 2).

What are the key physical properties of 3,5-Dimethyl-1-aminoadamantane?

Boiling Point: 239.8; Melting Point: 153; Solubility: 4.55e-02 g/L; LogP: 3.28.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.