6-氟-3-羟基吡嗪-2-甲酰胺

Description

6-Fluoro-3-hydroxypyrazine-2-carboxamide · CAS 259793-96-9 · C5H4FN3O2. UNII EW5GL2X7E0. Melting Point: 187℃ to 193℃; Dissociation Constants: 5.1.

Identification

CAS Registry Number	259793-96-9
PubChem CID	492405
Molecular formula	C5H4FN3O2
IUPAC name	5-fluoro-2-oxo-1H-pyrazine-3-carboxamide
UNII (FDA)	EW5GL2X7E0

Computed Descriptors

Molecular Weight	157.10
XLogP3	-0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	157.02875454
Monoisotopic Mass	157.02875454
Topological Polar Surface Area	84.6
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Melting Point	187℃ to 193℃
Dissociation Constants	5.1

Physical description & handling notes

• slightly soluble in water
• Favipiravir functions as a prodrug and undergoes ribosylation and phosphorylation intracellularly to become the active favipiravir-RTP. Favipiravir-RTP binds to and inhibits RNA dependent RNA polymerase (RdRp), which ultimately prevents viral transcription and replication.

GHS Hazard Classification

Reported hazard statements	H302 (40%), H315 (60%), H319 (60%), H335 (60%), H341 (20%), H361 (40%)

Documented Uses

• In 2014, favipiravir was approved in Japan to treat cases of influenza that were unresponsive to conventional treatment. Given its efficacy at targetting several strains of influenza, it has been investigated in other countries to treat novel viruses including Ebola and most recently, COVID-19.
• Breast Feeding; Lactation; Milk, Human; Antiviral Agents
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
• J - Antiinfectives for systemic use
• J05 - Antivirals for systemic use
• J05A - Direct acting antivirals

Synonyms

Favipiravir; 259793-96-9; 6-FLUORO-3-HYDROXYPYRAZINE-2-CARBOXAMIDE; avigan; T-705; 5-fluoro-2-oxo-1H-pyrazine-3-carboxamide; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide; T 705; Fapilavir; EW5GL2X7E0; Favilavir; T-705 cpd; T705; DTXSID60948878; 2-Pyrazinecarboxamide, 6-fluoro-3-hydroxy-; CHEBI:134722

Frequently Asked Questions

What are the CAS number and molecular formula of 6-Fluoro-3-hydroxypyrazine-2-carboxamide?

CAS 259793-96-9; molecular formula C5H4FN3O2; molecular weight — g/mol.

What other names is 6-Fluoro-3-hydroxypyrazine-2-carboxamide known by?

Favipiravir, 259793-96-9, 6-FLUORO-3-HYDROXYPYRAZINE-2-CARBOXAMIDE, avigan, T-705, 5-fluoro-2-oxo-1H-pyrazine-3-carboxamide.

Is 6-Fluoro-3-hydroxypyrazine-2-carboxamide classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H341.

What are the key physical properties of 6-Fluoro-3-hydroxypyrazine-2-carboxamide?

Melting Point: 187℃ to 193℃; Dissociation Constants: 5.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.