4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd)

Description

4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd) · CAS 140-64-7 · C19H24N4O2.2C2H6O4S. UNII V2P3K60DA2. Melting Point: 370 to 378 °F (NTP, 1992); Solubility: Water > 30 (mg/mL); Solubility: 0.1 N HCl ~2.5 (mg/mL).

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Pentamidine isethionate appears as odorless white or almost white crystals or powder. Odor also reported as a slight butyric odor. Very bitter taste. pH (5% aqueous solution) 4.5-6.5. (NTP, 1992)
• greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
• Acetate buffer, pH 4 ~2.5 (mg/mL)
• Carbonate buffer, pH 9 < 1 (mg/mL)
• Dimethyl acetamide ~15 (mg/mL)
• Dimethyl sulfoxide ~15 (mg/mL)

GHS Hazard Classification

Documented Uses

• For the treatment of pneumonia due to <i>Pneumocystis carinii</i>.
• Pentamidine isethionate is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment and prevention of Pneumocystis pneumonia (PCP). The FDA-approved uses for pentamidine isethionate depend on the dosage form of the drug. Specifically, pentamidine isethionate injection is approved to treat PCP, and pentamidine isethionate inhalant is approved to prevent PCP in people with HIV who are at high risk of developing PCP.
• PCP can be an opportunistic infection (OI) of HIV.
• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
• Substances that are destructive to protozoans.
• Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Synonyms

PENTAMIDINE ISETHIONATE; 140-64-7; Pentamidine diisethionate; 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate); Pentamidine isetionate; Pentacarinat; Nebupent; Pentamidine diisetionate; Diamidine; Lomidin; Pneumopent; Lomidine isoethionate; PENTAM; USAF XR-10; DTXSID5023796; RP 2512

Frequently Asked Questions

What are the CAS number and molecular formula of 4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd)?

CAS 140-64-7; molecular formula C19H24N4O2.2C2H6O4S; molecular weight — g/mol.

What other names is 4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd) known by?

PENTAMIDINE ISETHIONATE, 140-64-7, Pentamidine diisethionate, 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate), Pentamidine isetionate, Pentacarinat.

Is 4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd) classified as hazardous?

Hazard statements reported: H315, H317, H319, H335.

What are the key physical properties of 4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd)?

Melting Point: 370 to 378 °F (NTP, 1992); Solubility: Water > 30 (mg/mL); Solubility: 0.1 N HCl ~2.5 (mg/mL); Solubility: 0.1 NaOH < 1 (mg/mL).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.