6-乙氧基-2-苯并噻唑磺酰胺

Description

6-ethoxy-2-benzothiazolesulfonamide · CAS 452-35-7 · C9H10N2O3S2. UNII Z52H4811WX. Melting Point: 188-190.5; Melting Point: 188-190.5 °C; Melting Point: 189 °C.

Identification

CAS Registry Number	452-35-7
PubChem CID	3295
Molecular formula	C9H10N2O3S2
IUPAC name	6-ethoxy-1,3-benzothiazole-2-sulfonamide
UNII (FDA)	Z52H4811WX

Computed Descriptors

Molecular Weight	258.3
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	258.01328453
Monoisotopic Mass	258.01328453
Topological Polar Surface Area	119
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	188-190.5
Melting Point	188-190.5 °C
Melting Point	189 °C
Solubility	40
Solubility	6.88e-01 g/L
LogP	2.01
LogP	log Kow = 2.01
LogP	0.4
LogP	1.91

Physical description & handling notes

• Solid
• CRYSTALS FROM ETHYL ACETATE + SKELLYSOLVE B
• WHITE OR SLIGHTLY YELLOW CRYSTALLINE POWDER
• ODORLESS
• SLIGHTLY SOL IN ALC, ACETONE, CHLOROFORM & ETHER; PRACTICALLY INSOL IN WATER
• Water solubility = 40 mg/l @ 25 deg

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
• Carbonic Anhydrase Inhibitors; Diuretics
• .../USED FOR/ ADJUNCTIVE TREATMENT OF CHRONIC SIMPLE (OPEN-ANGLE) GLAUCOMA, SECONDARY GLAUCOMA, & PREOPERATIVELY IN ACUTE ANGLE-CLOSURE GLAUCOMA TO LOWER INTRAOCULAR PRESSURE PRIOR TO SURGERY.
• EFFECTIVE DOSE APPEARS TO VARY FROM 125 TO 1000 MG/DAY, GIVEN ORALLY IN DIVIDED DOSES.
• MEDICATION (VET): AS DIURETIC IN MILD CONGESTIVE CARDIAC EDEMAS.
• For more Therapeutic Uses (Complete) data for ETHOXZOLAMIDE (6 total), please visit the HSDB record page.

Synonyms

ethoxzolamide; 452-35-7; 6-Ethoxy-2-benzothiazolesulfonamide; Ethoxyzolamide; Ethoxazolamide; Ethamide; Cardrase; 6-Ethoxy-1,3-benzothiazole-2-sulfonamide; Etoxzolamide; Glaucotensil; Diuretic C; Mingoral; 2-Benzothiazolesulfonamide, 6-ethoxy-; DTXSID1023021; U-4191; NSC-10679

Frequently Asked Questions

What are the CAS number and molecular formula of 6-ethoxy-2-benzothiazolesulfonamide?

CAS 452-35-7; molecular formula C9H10N2O3S2; molecular weight — g/mol.

What other names is 6-ethoxy-2-benzothiazolesulfonamide known by?

ethoxzolamide, 452-35-7, 6-Ethoxy-2-benzothiazolesulfonamide, Ethoxyzolamide, Ethoxazolamide, Ethamide.

Is 6-ethoxy-2-benzothiazolesulfonamide classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of 6-ethoxy-2-benzothiazolesulfonamide?

Melting Point: 188-190.5; Melting Point: 188-190.5 °C; Melting Point: 189 °C; Solubility: 40.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.