1,1-二甲基双胍盐酸盐

Description

1,1-dimethylbiguanide hydrochloride · CAS 15537-72-1 · C4H12ClN5. UNII 786Z46389E.

Identification

CAS Registry Number	15537-72-1
PubChem CID	14219
Molecular formula	C4H12ClN5
IUPAC name	3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
UNII (FDA)	786Z46389E

Computed Descriptors

Molecular Weight	165.62
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	165.0781231
Monoisotopic Mass	165.0781231
Topological Polar Surface Area	91.5
Heavy Atom Count	10
Formal Charge	0
Complexity	132

Physical description & handling notes

• Stable under recommended storage conditions. /Metformin hydrochloride/
• Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas. /Metformin hydrochloride/
• When heated to decomposition it emits toxic fumes of /nitric oxides/.
• pKa = 12.4 /Metformin hydrochloride/
• 123 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• MW: 165.63. Prisms from water, MP 232 °C; crystals from propanol, MP 218-220 °C. Freely soluble in water; slightly soluble in alcohol. Practically insoluble in ether, chloroform, acetone, methylene chloride. /Metformin hydrochloride/

GHS Hazard Classification

Reported hazard statements	H302 (99.6%), H315 (42.3%), H319 (64.5%), H335 (11.7%), H412 (15.1%)

Documented Uses

• For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.
• By reaction of dimethylamine hydrochloride with dicyandiamide to yield the base. /Metformin hydrochloride/
• Preparation: ... J.J. Sterne, United States of America patent 3174901 (1965 to Jan Marcel Didier Aron-Samuel). /Metformin/
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Biguanides
• Glucophage (Class: Other Substances, Added Date: 10-1998)
• Metformin hydrochloride tablets, USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus. /Included in US product label/

Synonyms

Metformin hydrochloride; 1115-70-4; Metformin HCL; 1,1-Dimethylbiguanide hydrochloride; Diabefagos; Glucophage; Siamformet; Benofomin; Walaphage; Fortamet; Riomet; Glucophage XR; Glumetza; Diabex; Metformin monohydrochloride; Apophage

Frequently Asked Questions

What are the CAS number and molecular formula of 1,1-dimethylbiguanide hydrochloride?

CAS 15537-72-1; molecular formula C4H12ClN5; molecular weight — g/mol.

What other names is 1,1-dimethylbiguanide hydrochloride known by?

Metformin hydrochloride, 1115-70-4, Metformin HCL, 1,1-Dimethylbiguanide hydrochloride, Diabefagos, Glucophage.

Is 1,1-dimethylbiguanide hydrochloride classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H412.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.