Pirfenidone

Description

Pirfenidone · CAS 53179-13-8 · C12H11NO. UNII D7NLD2JX7U. Melting Point: 109.

Identification

CAS Registry Number	53179-13-8
PubChem CID	40632
Molecular formula	C12H11NO
IUPAC name	5-methyl-1-phenylpyridin-2-one
UNII (FDA)	D7NLD2JX7U

Computed Descriptors

Molecular Weight	185.22
XLogP3	1.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	185.084063974
Monoisotopic Mass	185.084063974
Topological Polar Surface Area	20.3
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	109

Physical description & handling notes

• White solid from hot water
• 102-104 °C; also as MP 103-105 °C from benzene-light petroleum
• Solubule in methanol
• Stable under recommended storage conditions.
• Pirfenidone is a novel agent with anti-inflammatory, antioxidant, and antifibrotic properties. It may improve lung function and reduce the number of acute exacerbations in patients with idiopathic pulmonary fibrosis (IPF).
• Oral: capsules, 267 mg, Esbriet (InterMune)

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Prepd by phenylation of 5-methyl-2-pyridinone: S.M. Gadekar, United States of American patent 3839364 (1974 to Affiliates Med. Res.).
• By phytochemical rearrangement of N-phenyl-6-methylpyridinium-3-olate.
• Pirfenidone is indicated for the treatment of idiopathic pulmonary fibrosis (IPF). In Canada and Europe, it is approved in adults only.
• Pirfenidone is an orally available pyridinone derivative that inhibits collagen formation and is used to treat idiopathic pulmonary fibrosis. Elevations in serum enzyme levels during pirfenidone therapy are not uncommon, but it has yet to be implicated in cases of clinically apparent liver injury with jaundice.
• Esbriet is indicated for the treatment of idiopathic pulmonary fibrosis (IPF). /Included in US product label/
• Cigarette smoking reduces peak plasma concentrations and systemic exposure to pirfenidone by 32 and 54%, respectively. The manufacturer recommends that patients be encouraged to stop smoking prior to initiation of pirfenidone and to avoid smoking during therapy.

Synonyms

PIRFENIDONE; 53179-13-8; Esbriet; Pirespa; AMR-69; Pirfenidona; Pirfenidonum; 5-methyl-1-phenylpyridin-2-one; 2(1H)-Pyridinone, 5-methyl-1-phenyl-; 5-Methyl-1-phenyl-2(1H)-pyridone; AMR 69; DTXSID4045183; D7NLD2JX7U; NSC-748456; DTXCID2025183; CHEBI:32016

Frequently Asked Questions

What are the CAS number and molecular formula of Pirfenidone?

CAS 53179-13-8; molecular formula C12H11NO; molecular weight — g/mol.

What other names is Pirfenidone known by?

PIRFENIDONE, 53179-13-8, Esbriet, Pirespa, AMR-69, Pirfenidona.

Is Pirfenidone classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Pirfenidone?

Melting Point: 109.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.