Diisopropyl methylphosphonate

Public-database records for Diisopropyl methylphosphonate (CAS 1445-75-6), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Colorless liquid; [MSDSonline]
• Water solubility = 160 g/L at 25 °C
• Vapor pressure = 0.17 mmHg at 25 °C
• Vapor pressure= 0.267 kPa at 70 °C
• 28.8 dynes/cm

Reported physical properties

How this substance is indexed

Documented uses

• A byproduct from the manufacture of the nerve-agent Sarin (constitutes up to 20% of Sarin); [HSDB]
• May be used to simulate G-type chemical agents
• Phosphonic acid, P-methyl-, bis(1-methylethyl) ester: ACTIVE
• Diisopropyl methylphosphonate is a byproduct from the manufacture of the nerve-agent Sarin
• ... Three dose levels of diisopropyl methylphosphonate were applied to a shaved area on the backs of Yorkshire-Cross pigs: 400, 40, and 4 ug/sq cm. Additional animals were given 40 mg of diisopropyl methylphosphonate by sc injection, which was equivalent to the high dose applied dermally. Within 24 hr of injection, 91% of the sc administered dose was eliminated in the urine. After 5 days, no further amt was detected in the urine. All tissue specimens collected revealed less than 0.04 ug/g of tissue. For those pigs
• Single doses (225 mg/kg) of [14C]-radiolabeled diisopropyl methylphosphonate dissolved in polyethylene glycol were admin by gavage to fasted male mice, rats, and dogs ... In mice, the highest level of radioactivity (172 ug/ml) was noted in the blood at 15 min. In rats, plasma concn peaked at 151 ug/ml about 2 hr after cmpd admin ... In dogs, peak plasma concn also occurred at 2 hr post-admin at a concn of 276 ug/ml ... Approx 90% of the diisopropyl methylphosphonate was absorbed from the GI tract. This estimate is

Names this substance appears under

DIISOPROPYL METHYLPHOSPHONATE; 1445-75-6; Diisopropyl methanephosphonate; Bis(1-methylethyl) methylphosphonate; DTXSID5024051; Methylphosphonic acid bis(1-methylethyl)ester; 56V3OG5DC7; Phosphonic acid, methyl-, bis(1-methylethyl) ester; DTXCID304051; CHEBI:77325; Diisopropyl methylphosphonate (DIMP); RefChem:587905; 215-896-0; METHYLPHOSPHONIC ACID DIISOPROPYL ESTER; 2-[methyl(propan-2-yloxy)phosphoryl]oxypropane; MFCD00015022

Computed molecular descriptors

Database abstract

Diisopropyl methylphosphonate · CAS 1445-75-6 · C7H17O3P. UNII 56V3OG5DC7. 沸点: 121.05 °C @ 10 mm Hg; 沸点: 121.05 °C @760 [mm Hg]; 溶解度: In water, 1.50X10+3 mg/l @ 25 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.