difenidol

Public-database records for difenidol (CAS 972-02-1), reproduced here for independent cross-checking.

Physical description and handling notes

• Solid
• NEEDLES FROM PETROLEUM ETHER
• WHITE CRYSTALLINE POWDER
• ODORLESS
• SLIGHTLY BITTER TASTE
• CRYSTALS FROM CHLOROFORM + ETHYL ACETATE; FREELY SOL IN METHANOL; SOL IN WATER & CHLOROFORM; PRACTICALLY INSOL IN ETHER, BENZENE, & PETROLEUM ETHER /HCL/

Reported physical properties

How this substance is indexed

Documented uses

• MIESCHER, MARXER, US PATENT 2,411,644 (1946 TO CIBA); BARRETT, WILKINSON, BRITISH PATENT 683,950 (1952 TO WELLCOME FOUNDATION), CA 48, 2112E (1954).
• DIPHENIDOL IS DISSOLVED IN SUITABLE SOLVENT & REACTED WITH HYDROGEN CHLORIDE. /HCL/
• For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.
• Antiemetics; Histamine H1 Antagonists
• ...ANTIEMETIC AGENT FOR ORAL, RECTAL, IM, OR IV ADMIN, USEFUL IN MGMNT OF NAUSEA & VOMITING ASSOC WITH INFECTIOUS DISEASES, MALIGNANCIES, RADIATION SICKNESS, GENERAL ANESTHESIA, TREATMENT WITH ANTINEOPLASTIC AGENTS. ...ALSO USEFUL IN TREATMENT OF VERTIGO OF VESTIBULAR ORIGIN.
• IN ADULTS, THIS DRUG ALSO IS EFFECTIVE IN...LABYRINTHITIS FOLLOWING SURGERY OF MIDDLE & INNER EAR, & MENIERE'S DISEASE. ITS USE IN TREATMENT OF VERTIGO IN CHILDREN HAS NOT BEEN INVESTIGATED. /HCL/

Names this substance appears under

DIPHENIDOL; Difenidol; 972-02-1; Nometic; Avomol; Difenidolo; Difenidolum; 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol; alpha,alpha-Diphenyl-1-piperidinebutanol; Diphenyl(3-(1-piperidyl)propyl)carbinol; SKF 478; SK&F 478; SK&F-478; SK-478; DTXSID3022950; NQO8R319LY

Computed molecular descriptors

Database abstract

difenidol · CAS 972-02-1 · C21H27NO. UNII NQO8R319LY. 熔点: 212-214; 熔点: 104-105 °C; 溶解度: 5.87e-03 g/L.

Source: PubChem / Wikidata; the batch COA governs where values differ.