Dihydroergotamine mesilate

Name: Dihydroergotamine mesilate
Brand: Jinan Shenghe Chemical Co., Ltd.
SKU: 9747

CAS 6190-39-2C33H37N5O5MW 583.7

Dihydroergotamine mesilate (CAS 6190-39-2) — formula C33H37N5O5, molecular weight 583.7.

Specifications

CAS Number6190-39-2

Molecular FormulaC33H37N5O5

Molecular Weight583.7

LogP2.4

ApplicationsUses: Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 2.8, Dihydroergotamine is a 9, 10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. Ergoline alkaloids occurs in various species of vines of the Convolvulaceae (morning glory) family and in some species of lower fungi. (L1918, L1932) For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes., Use Classification: Pharmaceuticals

Where it is used

Documented applications: Uses: Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 2.8, Dihydroergotamine is a 9, 10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. Ergoline alkaloids occurs in various species of vines of the Convolvulaceae (morning glory) family and in some species of lower fungi. (L1918, L1932) For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes., Use Classification: Pharmaceuticals.

Purchase Profile

What this product is

Dihydroergotamine mesilate is a chemical compound with CAS registry number 6190-39-2 and molecular formula C33H37N5O5 (molecular weight 583.7).

Identification

CAS number: 6190-39-2

Its molecular formula C33H37N5O5 comprises 33 C, 37 H, 5 N, 5 O atoms.

Also known as: Dihydroergotamine mesilate · Dihydroergotamine Mesylate

Frequently Asked Questions

What is the CAS number of Dihydroergotamine mesilate?

The CAS registry number of Dihydroergotamine mesilate is 6190-39-2.

What is the molecular formula and molecular weight of Dihydroergotamine mesilate?

Molecular formula C33H37N5O5, molecular weight 583.7.

What other names is Dihydroergotamine mesilate known by?

It is also registered under: Dihydroergotamine mesilate, Dihydroergotamine Mesylate.

What are the documented applications of Dihydroergotamine mesilate?

Recorded applications: Uses: Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 2.8, Dihydroergotamine is a 9, 10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. Ergoline alkaloids occurs in various species of vines of the Convolvulaceae (morning glory) family and in some species of lower fungi. (L1918, L1932) For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes., Use Classification: Pharmaceuticals.

PubChem Public Data

Public-database records for Dihydroergotamine mesilate (CAS 6190-39-2), reproduced here for independent cross-checking.

Safety classification and hazard statements

Reported hazard statements	H302 (66.7%), H312 (33.3%), H332 (66.7%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]

Physical description and handling notes

Solid
227.09 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Reported physical properties

溶解度	2.29e-01 g/L

How this substance is indexed

CAS Registry Number	6190-39-2
PubChem CID	10531
分子式	C33H37N5O5
IUPAC 名称	(6aR,9R,10aR)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
UNII（FDA）	436O5HM03C

Documented uses

Use (kg; approx.) in Germany (2009): >25
Consumption (g per capita; approx.) in Germany (2009): 0.000305
Dihydroergotamine is a 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. Ergoline alkaloids occurs in various species of vines of the Convolvulaceae (morning glory) family and in some species of lower fungi. (L1918, L1932) For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Dihydroergotamine (DHE) in all formulations is indicated for the acute treatment of migraine with or without aura in adults. As an injection, DHE is also indicated for the acute treatment of cluster headache episodes. DHE is not indicated for migraine prevention or the management of hemiplegic or basilar migraine.
Breast Feeding; Lactation; Analgesics, Non-Narcotic; Dopamine Agonists; Vasoconstrictor Agents
Dihydroergotamine (Class: Other Substances, Added Date: 07-2003)

Names this substance appears under

dihydroergotamine; 511-12-6; 9,10-Dihydroergotamine; Dihidroergotamina; Dihydroergotaminum; Neomigran; Diidroergotamina; Agit; MAP0004; DTXSID6045614; MAP-0004; 436O5HM03C; CHEBI:4562; DTXCID4025614; 5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman; 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione

Computed molecular descriptors

分子量	583.7
XLogP3	2.4
氢键供体数	3
氢键受体数	6
可旋转键数	4
精确质量	583.27946930
单同位素质量	583.27946930
拓扑极性表面积	118
重原子数	43
形式电荷	0

Database abstract

Dihydroergotamine mesilate · CAS 6190-39-2 · C33H37N5O5. UNII 436O5HM03C. 溶解度: 2.29e-01 g/L.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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