Cytisine

Public-database records for Cytisine (CAS 485-35-8), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Orthorhombic prisms from acetone
• Solid
• Soluble in 13 parts acetone, 1.3 parts methanol, 3.5 parts alcohol, 30 parts benzene, 10 parts ethyl acetone, 2.0 parts chloroform; practically insoluble in petroleum ether
• Soluble in 1.3 parts water
• Needles or leaflets. Specific optical rotation: -81.5 deg at 25 °C/D; soluble in water, slightly soluble in alcohol; practically insoluble in ether /Cytisine nitrate monohydrate/
• Specific optical rotation: -120 deg at 17 °C/D

Reported physical properties

How this substance is indexed

Documented uses

• Formerly used as an antitussive and antiemetic
• Cytisine was obtained from Laburnum anagyroides by extraction of the powdered dry seeds with ethyl alcohol-hydrochloric acid, distillation of the alcohol, dilution with water, filtration, and precipitation of the alkaloid with Mayer's reagent.
• The isolation and identification of cytisine is described.
• 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)-: ACTIVE
• Toxic principle in seed of Laburnum anagyroides Medik /golden chain tree/, and other Leguminosae.
• Tabex contains cytisine and is used to aid chronic smokers in abstaining from smoking. Total abstentation occurred in 65.1% of the subjects.

Names this substance appears under

CYTISINE; 485-35-8; Baptitoxine; Cytisinicline; Sophorine; Baptitoxin; Cytiton; Laburnin; Ulexine; Ulexin; Cytitone; Citizin; Cystisine; Cytizin; (1r,5s)-1,2,3,4,5,6-Hexahydro-8h-1,5-Methanopyrido[1,2-A][1,5]diazocin-8-One; 6039 Sopharma

Computed molecular descriptors

Database abstract

Cytisine · CAS 485-35-8 · C11H14N2O. UNII 53S5U404NU. 沸点: 218; 沸点: BP: 218 °C at 2 mm Hg; 熔点: 152-153.

Source: PubChem / Wikidata; the batch COA governs where values differ.