Chloroquine Phosphate

Public-database records for Chloroquine Phosphate (CAS 50-63-5), reproduced here for independent cross-checking.

Physical description and handling notes

• 175.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

How this substance is indexed

Documented uses

• For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis (A308).
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Information on 1 consumer products that contain Chloroquine phosphate in the following categories is provided:
• Breast Feeding; Lactation; Milk, Human; Anti-infective Agents; Antiparasitic Agents; Antimalarials; Antirheumatic Agents; Antiprotozoal Agents
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

Names this substance appears under

Chloroquine diphosphate; Chloroquine phosphate; Aralen phosphate; Resochin; Arechin; Avloclor; Delagil; Chingamin phosphate; Chloroquini phosphas; NSC-14050; 6E17K3343P; SN-7618; WR-1522; 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2); 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2); N(4)-(7-Chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, phosphate (1:2)

Computed molecular descriptors

Database abstract

Chloroquine Phosphate · CAS 50-63-5 · C18H32ClN3O8P2. UNII 6E17K3343P.

Source: PubChem / Wikidata; the batch COA governs where values differ.