Levofloxacin（CAS 100986-85-4）：分子式 C18H20FN3O4、分子量 361.4。
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >7500、exact) in Germany (2009): 7956、Use (kg) in USA (2002): 45200、Consumption (g per capita、approx.) in Germany (2009): 0.0916、exact) in Germany (2009): 0.0972、Consumption (g per capita) in the USA (2002): 0.16、Excretion rate: 0.85、Calculated removal (%): 1.9、For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium<、i> species、<i>Staphylococus aureus<、i>、<i>Staphylococcus epidermidis<、<i>Streptococcus pneumoniae<、<i>Streptococcus<、i> (Groups C、F、G)、Viridans group streptococci、<i>Acinetobacter lwoffii<、<i>Haemophilus influenzae<、<i>Serratia marcescens<、i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).、Use Classification: Pharmaceuticals、Formulations、Preparations: Table: Levofloxacin Preparations [Table#7973]、Parenteral Injection、for IV infusion: equivalent to levofloxacin 5 mg、mL (250、500、or 750 mg) in 5% Dextrose、Levaquin in Dextrose Injection Premix (in flexible containers) (Ortho-McNeil).、Ophthalmic: Solution 0.5%、Quixin (Vistakon)、Tavanic (levofloxacin、250 and 500 mg film-coated tablets and 5mg、mL solution for infusion)、General Manufacturing Information: The more active levo isomer of ofloxacin (a racemic mixture of D、L、-isomers) that has improved activity against gram-potitive pathogens (in particular against S. pneumoniae) compared to ciprofloxacin.、Prepared as the hemihydrate、The methyl group at the C-3 position in the oxazine ring results in the formation of isoenantiomers、ofloxacin occurs as a racemic mixture of the two isomers. The S-(-)isomer is 8-128 times as active against susceptible gram-positive and gram-negative organisms as the R-(+)isomer and approximately twice as active as racemic ofloxacin.。
Levofloxacin 是一种化工化合物，登记 CAS 号为 100986-85-4，分子式 C18H20FN3O4（分子量 361.4）。
登记 CAS 号：100986-85-4
其分子式 C18H20FN3O4 由 18 个碳、20 个氢、1 个氟、3 个氮、4 个氧 组成。
别名/同义词：Levofloxacin · Levofloxacin Hemihydrate
Levofloxacin 的 CAS 登记号为 100986-85-4。
分子式 C18H20FN3O4，分子量 361.4。
别名/同义词：Levofloxacin、Levofloxacin Hemihydrate。
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >7500、exact) in Germany (2009): 7956、Use (kg) in USA (2002): 45200、Consumption (g per capita、approx.) in Germany (2009): 0.0916、exact) in Germany (2009): 0.0972、Consumption (g per capita) in the USA (2002): 0.16、Excretion rate: 0.85、Calculated removal (%): 1.9、For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium<、i> species、<i>Staphylococus aureus<、i>、<i>Staphylococcus epidermidis<、<i>Streptococcus pneumoniae<、<i>Streptococcus<、i> (Groups C、F、G)、Viridans group streptococci、<i>Acinetobacter lwoffii<、<i>Haemophilus influenzae<、<i>Serratia marcescens<、i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).、Use Classification: Pharmaceuticals、Formulations、Preparations: Table: Levofloxacin Preparations [Table#7973]、Parenteral Injection、for IV infusion: equivalent to levofloxacin 5 mg、mL (250、500、or 750 mg) in 5% Dextrose、Levaquin in Dextrose Injection Premix (in flexible containers) (Ortho-McNeil).、Ophthalmic: Solution 0.5%、Quixin (Vistakon)、Tavanic (levofloxacin、250 and 500 mg film-coated tablets and 5mg、mL solution for infusion)、General Manufacturing Information: The more active levo isomer of ofloxacin (a racemic mixture of D、L、-isomers) that has improved activity against gram-potitive pathogens (in particular against S. pneumoniae) compared to ciprofloxacin.、Prepared as the hemihydrate、The methyl group at the C-3 position in the oxazine ring results in the formation of isoenantiomers、ofloxacin occurs as a racemic mixture of the two isomers. The S-(-)isomer is 8-128 times as active against susceptible gram-positive and gram-negative organisms as the R-(+)isomer and approximately twice as active as racemic ofloxacin.。
Levofloxacin（CAS 100986-85-4）的公开数据库记录，列此仅供独立核对。
| Reported hazard statements | H302 (98.3%), H317 (96%), H334 (97.1%), H361 (54.6%), H362 (53.4%) |
|---|
H302 (98.3%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (96%): May cause an allergic skin reaction [Warning Sensitization, Skin]
| 熔点 | 225-227C |
|---|---|
| 熔点 | 225-227 °C (decomposes) |
| LogP | 2.1 |
| LogP | log Kow = -0.39 |
| Dissociation Constants | 8.12 |
| Dissociation Constants | 6.1 |
| Dissociation Constants | 8.6 |
| Dissociation Constants | 6.25 |
| CAS Registry Number | 100986-85-4 |
|---|---|
| PubChem CID | 149096 |
| 分子式 | C18H20FN3O4 |
| IUPAC 名称 | (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
| UNII（FDA） | RIX4E89Y14 |
LEVOFLOXACIN; 100986-85-4; Levaquin; Quixin; (-)-Ofloxacin; Iquix; Cravit; (S)-Ofloxacin; Levofloxacine; Tavanic; Levofloxacino; Levofloxacinum; Elequine; Oftaquix; L-Ofloxacin; Floxacin
| 分子量 | 361.4 |
|---|---|
| XLogP3 | -0.4 |
| 氢键供体数 | 1 |
| 氢键受体数 | 8 |
| 可旋转键数 | 2 |
| 精确质量 | 361.14378429 |
| 单同位素质量 | 361.14378429 |
| 拓扑极性表面积 | 73.3 |
| 重原子数 | 26 |
| 形式电荷 | 0 |
Levofloxacin · CAS 100986-85-4 · C18H20FN3O4. UNII RIX4E89Y14. 熔点: 225-227C; 熔点: 225-227 °C (decomposes); LogP: 2.1.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。