Tris(hydroxymethyl)aminomethane (CAS 77-86-1) — formula C4H11NO3, molecular weight 121.14; category pharmaceutical intermediates and APIs.
Documented applications: Pharmaceutical Intermediates &, APIs, Pharmaceutical Raw Materials.
Tris(hydroxymethyl)aminomethane is a pharmaceutical intermediate or API compound with CAS registry number 77-86-1 and molecular formula C4H11NO3 (molecular weight 121.14), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 77-86-1
Its molecular formula C4H11NO3 comprises 4 C, 11 H, 1 N, 3 O atoms.
Also known as: Tris(hydroxymethyl)aminomethane · Tris Base
Category: pharmaceutical intermediates and APIs
The CAS registry number of Tris(hydroxymethyl)aminomethane is 77-86-1.
Molecular formula C4H11NO3, molecular weight 121.14.
It is also registered under: Tris(hydroxymethyl)aminomethane, Tris Base.
Recorded applications: Pharmaceutical Intermediates &, APIs, Pharmaceutical Raw Materials.
Category: Pharmaceutical Raw Materials.
Public-database records for Tris(hydroxymethyl)aminomethane (CAS 77-86-1), reproduced here for independent cross-checking.
| GHS 通报统计 | 19.7% (235 / 1192) |
|---|---|
| 已通报的危害声明 | H315 (80.2%), H319 (80.3%), H335 (70.8%) |
| 法规与食品接触 | CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS 通报统计 | 19.7% (235 / 1192) |
| 沸点 | 219-220 °C at 10 mm Hg |
|---|---|
| 熔点 | 171-172 °C |
| 溶解度 | In water, 5.50X10+5 mg/L at 25 °C |
| 蒸气压 | 0.000022 [mmHg] |
| Ionization Efficiency | 2.41 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1007/s13361-016-1563-2 |
| Dissociation Constants | 8.08 |
| Dissociation Constants | pKa = 8.07 |
| CAS 号 | 77-86-1 |
|---|---|
| PubChem CID | 6503 |
| 分子式 | C4H11NO3 |
| IUPAC 名称 | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| UNII（FDA） | 023C2WHX2V |
氨丁三醇；氨丁三醇； 77-86-1；三(羟甲基)氨基甲烷；谭；三胺； 2-氨基-2-(羟甲基)-1,3-丙二醇； Tris缓冲液；氨丁三醇； Tris碱基；三氨基酚；行为规范；塔拉特罗； Tutofusin tris; Tris-不育；阿德克斯塔姆
| 分子量 | 121.14 |
|---|---|
| XLogP3 | -2.9 |
| 氢键供体数 | 4 |
| 氢键受体数 | 4 |
| 可旋转键数 | 3 |
| 精确质量 | 121.07389321 |
| 单同位素质量 | 121.07389321 |
| 拓扑极性表面积 | 86.7 |
| 重原子数 | 8 |
| 形式电荷 | 0 |
三羟甲基氨基甲烷 · CAS 77-86-1 · C4H11NO3. UNII 023C2WHX2V. 沸点: 219-220 °C at 10 mm Hg; 熔点: 171-172 °C; 溶解度: In water, 5.50X10+5 mg/L at 25 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd. · Reply within one business day.