Vitamin K3

Vitamin K3 (CAS 58-27-5) — formula C11H8O2, molecular weight 172.05 g/mol; category food additives.

Specifications

Where it is used

Documented applications: Uses: Synthetic naphthoquinone derivative with the physiologic properties of vitamin K, Used as a supplement and veterinary antidote to bishydroxycoumarin poisoning (including sweet clover poisoning), [Merck Index] Used as an intermediate in phylloquinone production, [IARC], Vitamin (prothrombogenic, VET: Vitamin (prothrombogenic), antidote to bishydroxycoumarin poisoning, including sweet clover poisoning., Dimethylpyrimidinol bisulfite menadione, MEDICINE, FUNGICIDES, ANIMAL FEED ADDITIVES, Menadione is of industrial importance as an intermediate in the synthesis of phylloquinone, and salts of its bisulfite adduct are used as stabilized forms in the animal feed industry., For menadione (USEPA, OPP Pesticide Code: 006319) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification., Use Classification: Cosmetics -> Masking, Methods of Manufacturing: It is obtained from 2-methylnaphthalene in 70-90% yield by oxidation with chromic acid. Slightly lower yields are obtained with chromium trioxide in conjunction with crown ethers., Formulations, Preparations: MENADIONE, NF (VIT K3)...AVAIL IN ORAL ADMIN IN TABLETS CONTAINING 2, 5, OR 10 MG, & AS STERILE SOLN OF MENADIONE IN OIL (USUALLY 2, 10, OR 25 MG, ML) DESIGNED FOR IM ADMIN., MENADIONE SODIUM BISULFITE, NF (HYKINONE)...WHITE CRYSTALLINE, HYGROSCOPIC POWDER. ...SOL IN WATER...MARKETED IN 5-MG TABLETS & IN AMPULS... 5-10 MG, ML. MENADIOL SODIUM DIPHOSPHATE INJECTION, NF (KAPPADIONE, SYNKAVITE)...AMPULS...5, OR 37.5 MG, ML. MENADIOL SODIUM DIPHOSPHATE TABLETS, NF...5 MG..., MENADIOL SODIUM DIPHOSPHATE INJECTION, SYNKAVITE), IS MARKETED IN AMPULS CONTAINING 5, NF, CONTAIN 5 MG OF SALT FOR ORAL USE., Commercially significant forms are menadione sodium bisulfite and menadione dimethyl pyrimidinol., For more Formulations, Preparations (Complete) data for MENADIONE (6 total), please visit the HSDB record page., General Manufacturing Information: 1, 4-Naphthalenedione, 2-methyl-: ACTIVE, ...CORN STIGMA CONTAINS ALC SOL SUBSTANCE TERMED BY..., MIKHLIN CR, VIT K3, HOWEVER...DIFFERENTIATION FROM VIT K1 IS NOT CLEAR. IN ANGLO-AMERICAN LITERATURE...K3 DESIGNATES MENADIONE. THIS DESIGNATION SHOULD BE DISCONTINUED...DERIV OF 1, 4-NAPHTHOQUINONE WITHOUT SIDECHAIN IN 3-POSITION CANNOT EXERT ALL FUNCTIONS OF K VIT..., ...MENADIONE OR VIT K3...DEPENDING ON BIOASSAY SYSTEM USED, @ LEAST AS ACTIVE ON MOLAR BASIS AS PHYLLOQUINONE. ...ACTIVE WATER-SOL DERIVATIVES OF MENADIONE...SODIUM-BISULFITE SALT OR TETRASODIUM SALT OF DIPHOSPHORIC ACID ESTER. THESE COMPD ARE CONVERTED IN BODY TO MENADIONE., PARENT STRUCTURE OF K FAMILY OF VIT IS 2-METHYL-1, 4-NAPHTHOQUINONE OR MENADIONE. THIS FAT-SOL COMPD & SEVERAL WATER-SOL DERIVATIVES SUCH AS SODIUM BISULFITE & DIPHOSPHORIC ACID ESTER ARE COMMON COMMERCIAL FORMS USED IN MEDICAL PRACTICE., NATURAL, FAT-SOL VIT ARE MORE EFFECTIVE THAN WATER-SOL DERIVATIVES., VIT K, DRUGS WITH VIT K ACTIVITY MAY BE CHEMICALLY ASSAYED & DO NOT REQUIRE BIOASSAY. ...DETERMINATION OF VIT K CONTENT OF FOODS, ASSAY BASED UPON ABILITY OF PREPN TO INCR PROTHROMBIC LEVEL OF DEFICIENT CHICKS IS EMPLOYED..

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What this product is

Vitamin K3 is a food-grade compound with CAS registry number 58-27-5 and molecular formula C11H8O2 (molecular weight 172.05 g/mol), belonging to the food additives segment of chemical raw materials.

Identification

CAS number: 58-27-5

Its molecular formula C11H8O2 comprises 11 C, 8 H, 2 O atoms.

Also known as: Vitamin K3 · 2-Methyl-1,4-naphthoquinone

Category: food additives

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