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Stavudine

CAS 220020-60-0C10H12N2O4MW 224.21

Stavudine (CAS 220020-60-0) — formula C10H12N2O4, molecular weight 224.21.

Specifications

CAS Number220020-60-0
Molecular FormulaC10H12N2O4
Molecular Weight224.21
Melting Point318 to 320 °F (NTP, 1992)
LogP-0.72

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What this product is

Stavudine is a chemical compound with CAS registry number 220020-60-0 and molecular formula C10H12N2O4 (molecular weight 224.21).

Identification

CAS number: 220020-60-0

Its molecular formula C10H12N2O4 comprises 10 C, 12 H, 2 N, 4 O atoms.

Also known as: Stavudine

Frequently Asked Questions

What is the CAS number of Stavudine?

The CAS registry number of Stavudine is 220020-60-0.

What is the molecular formula and molecular weight of Stavudine?

Molecular formula C10H12N2O4, molecular weight 224.21.

What other names is Stavudine known by?

It is also registered under: Stavudine.

PubChem Public Data

Public-database records for Stavudine (CAS 220020-60-0), reproduced here for independent cross-checking.

Safety classification and hazard statements

Reported hazard statementsH302 (66.7%), H315 (33.3%), H319 (33.3%), H335 (33.3%), H341 (33.3%), H361 (33.3%), H362 (33.3%), H372 (33.3%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]

Physical description and handling notes

  • 2',3'-didehydro-3'-deoxythymidine appears as white crystalline solid or powder. Odorless. (NTP, 1992)
  • Solid
  • White to off white crystalline solid
  • Colorless granular solid from ethanol/benzene
  • 30 mg/mL in propylene glycol at 23 °C
  • 9.5X10-12 mm Hg at 25 °C /Estimated/

Reported physical properties

熔点318 to 320 °F (NTP, 1992)
熔点159-160 °C
熔点165-166 °C
熔点159 - 160 °C
溶解度50 to 100 mg/mL at 70 °F (NTP, 1992)
溶解度5-10 g/100 mL at 21 °C
溶解度In water, 83 mg/mL at 23 °C
溶解度4.05e+01 g/L
LogP-0.72
LogPlog Kow = -0.72 at 37 °C

How this substance is indexed

CAS Registry Number220020-60-0
PubChem CID18283
分子式C10H12N2O4
IUPAC 名称1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
UNII（FDA）BO9LE4QFZF

Documented uses

  • Use (kg; approx.) in Germany (2009): >10
  • Consumption (g per capita; approx.) in Germany (2009): 0.000122
  • Consumption (g per capita) in the USA (2002): 0.00425
  • For the treatment of human immunovirus (HIV) infections.
  • Large scale production: J.E. Starrett et al, EP 334368; eidem, US 5130421 (1989, 1992 both to Bristol-Myers)
  • Stavudine is a first generation nucleoside analogue and reverse transcriptase inhibitor used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Stavudine is an uncommon, but well established cause of clinically apparent acute and chronic liver injury.

Names this substance appears under

stavudine; 3056-17-5; sanilvudine; Zerit; 2',3'-Didehydro-3'-deoxythymidine; Estavudina; Stavudinum; Thymidine, 2',3'-didehydro-3'-deoxy-; Zerit Xr; BMY-27857; 3'-Deoxy-2'-thymidinene; 1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; D 4T (nucleoside); 2',3'-Didehydro-3'-deoxythimidine; 3'-Deoxy-2',3'-didehydrothymidine; BMY 27857

Computed molecular descriptors

分子量224.21
XLogP3-0.8
氢键供体数2
氢键受体数4
可旋转键数2
精确质量224.07970687
单同位素质量224.07970687
拓扑极性表面积78.9
重原子数16
形式电荷0

Database abstract

Stavudine · CAS 220020-60-0 · C10H12N2O4. UNII BO9LE4QFZF. 熔点: 318 to 320 °F (NTP, 1992); 熔点: 159-160 °C; 熔点: 165-166 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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