Levodopa (CAS 59-92-7) — formula C9H11NO4, molecular weight 197.07 g/mol.
Documented applications: Uses: Natural form of dopa (precursor of the catecholamines), Used to treat Parkinson's disease, [Merck Index], MEDICATION, Use (kg) in Switzerland (2009): >2500, Use (kg, approx.) in Germany (2009): >25000, Use (kg) in USA (2002): 26200, Use (kg) in France (2004): 24996, Consumption (g per capita) in Switzerland (2009): 0.32, Consumption (g per capita, approx.) in Germany (2009): 0.31, Consumption (g per capita) in the USA (2002): 0.093, Consumption (g per capita) in France (2004): 0.41, Excretion rate: 0.5, Calculated removal (%): 75.1, For the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication., Use Classification: Pharmaceuticals, Methods of Manufacturing: Derived from several types of beans including vanilla., Preparation from L-tyrosine: Vorbruggen, Krolikiewicz, Ber. 105, 1168 (1972), Bretschneider et al., Helv. Chim. Acta 56, 2857 (1973), from Vicia faba beans: Wysong, US 3253023 (1966 to Dow Chem.), by fermentation of L-tyrosine: Sih et al., J. Am. Chem. Soc. 91, 6204 (1969), Florent, Renaut, DE 2102793 (1971 to Rhone-Poulenc), C.A. 75, 108505f (1971). Separation from racemate: Vogler, Baumgartner, Helv. Chim. Acta 35, 1776 (1952), NL 6514950, US 3405159 (1966, 1968 both to Merck & Co.), Production: glycine + acetic anhydride + vanillin (amide formation, carbonyl condensation, chiral catalytic hydrogenation, hydrolysis. Production: 2, 4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis, racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion), Formulations, Preparations: CAPSULES USP: 100, 250, & 500 MG, TABLETS USP: 100, & 500 MG., Levodopa is one of the main ingredients along with carbidopa in the drug Sinemet ... (tablets), Levodopa is one of the main ingredients along with carbidopa in the drug Atamet ... (tablets), General Manufacturing Information: L-Tyrosine, 3-hydroxy-: ACTIVE.
Levodopa is a chemical compound with CAS registry number 59-92-7 and molecular formula C9H11NO4 (molecular weight 197.07 g/mol).
CAS number: 59-92-7
Its molecular formula C9H11NO4 comprises 9 C, 11 H, 1 N, 4 O atoms.
Also known as: Levodopa · L-DOPA
The CAS registry number of Levodopa is 59-92-7.
Molecular formula C9H11NO4, molecular weight 197.07 g/mol.
It is also registered under: Levodopa, L-DOPA.
Recorded applications: Uses: Natural form of dopa (precursor of the catecholamines), Used to treat Parkinson's disease, [Merck Index], MEDICATION, Use (kg) in Switzerland (2009): >2500, Use (kg, approx.) in Germany (2009): >25000, Use (kg) in USA (2002): 26200, Use (kg) in France (2004): 24996, Consumption (g per capita) in Switzerland (2009): 0.32, Consumption (g per capita, approx.) in Germany (2009): 0.31, Consumption (g per capita) in the USA (2002): 0.093, Consumption (g per capita) in France (2004): 0.41, Excretion rate: 0.5, Calculated removal (%): 75.1, For the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication., Use Classification: Pharmaceuticals, Methods of Manufacturing: Derived from several types of beans including vanilla., Preparation from L-tyrosine: Vorbruggen, Krolikiewicz, Ber. 105, 1168 (1972), Bretschneider et al., Helv. Chim. Acta 56, 2857 (1973), from Vicia faba beans: Wysong, US 3253023 (1966 to Dow Chem.), by fermentation of L-tyrosine: Sih et al., J. Am. Chem. Soc. 91, 6204 (1969), Florent, Renaut, DE 2102793 (1971 to Rhone-Poulenc), C.A. 75, 108505f (1971). Separation from racemate: Vogler, Baumgartner, Helv. Chim. Acta 35, 1776 (1952), NL 6514950, US 3405159 (1966, 1968 both to Merck & Co.), Production: glycine + acetic anhydride + vanillin (amide formation, carbonyl condensation, chiral catalytic hydrogenation, hydrolysis. Production: 2, 4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis, racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion), Formulations, Preparations: CAPSULES USP: 100, 250, & 500 MG, TABLETS USP: 100, & 500 MG., Levodopa is one of the main ingredients along with carbidopa in the drug Sinemet ... (tablets), Levodopa is one of the main ingredients along with carbidopa in the drug Atamet ... (tablets), General Manufacturing Information: L-Tyrosine, 3-hydroxy-: ACTIVE.
Public-database records for Levodopa (CAS 59-92-7), reproduced here for independent cross-checking.
| 已通报的危害声明 | H302 (100%), H315 (32.2%), H319 (52.9%), H335 (30.8%), H361 (30.3%), H372 (14.4%), H411 (26.9%), H412 (15.9%) |
|---|
| 沸点 | 448.4 |
|---|---|
| 熔点 | 295 |
| 熔点 | 284-286 °C |
| 熔点 | 285 °C |
| 溶解度 | 5mM |
| 溶解度 | In water, 5,000 mg/l @ 20 °C |
| 溶解度 | 5.0 mg/mL |
| LogP | 0.05 |
| LogP | log Kow = -2.39 |
| LogP | -2.39 |
| CAS 号 | 59-92-7 |
|---|---|
| PubChem CID | 6047 |
| 分子式 | C9H11NO4 |
| 分子量 | 197.07 g/mol |
| IUPAC 名称 | (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid |
| InChIKey | WTDRDQBEARUVNC-LURJTMIESA-N |
| UNII（FDA） | 46627O600J |
| ChEBI 编号 | CHEBI:15765 |
| ATC 编码（WHO） | N04BA01 |
levodopa; L-dopa; 59-92-7; 3,4-dihydroxy-L-phenylalanine; Dopar; 3-Hydroxy-L-tyrosine; Larodopa; Bendopa; 3-(3,4-Dihydroxyphenyl)-L-alanine; Levopa; Brocadopa; Dopaidan; Dopalina; Dopasol; Eldopal; Insulamina
| 分子量 | 197.19 |
|---|---|
| XLogP3 | -2.7 |
| 氢键供体数 | 4 |
| 氢键受体数 | 5 |
| 可旋转键数 | 3 |
| 精确质量 | 197.06880783 |
| 单同位素质量 | 197.06880783 |
| 拓扑极性表面积 | 104 |
| 重原子数 | 14 |
| 形式电荷 | 0 |
L-DOPA 的 CAS 号为 59-92-7，分子式 C9H11NO4，分子量 197.07 g/mol。 UNII 46627O600J; ChEBI 15765; InChIKey WTDRDQBEARUVNC-LURJTMIESA-N. 沸点: 448.4; 熔点: 295; 熔点: 284-286 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
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