Choline Chloride FCC (CAS 67-48-1) — formula C5H14NO.Cl, molecular weight 139.62; category inorganic chemicals.
Documented applications: Uses: CIR ingredient: Choline Chloride, Therap cat: lipotropic, Therap cat (vet): Nutritional factor. Dietary source of choline (lipotropic factor) in poultry., MEDICATION, MEDICATION (VET), MEDICATION (VET): Animal feed additive derived from agricultural waste or made synthetically. Available as 50% dry feed-grade & 70% soln., Use (kg, approx.) in Germany (2009): >750, Consumption (g per capita, approx.) in Germany (2009): 0.00916, Calculated removal (%): 92.1, Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Flavoring Agents -> JECFA Flavorings Index, Industry Uses: Processing aids, specific to petroleum production, Abrasives, Soil amendments (fertilizers), Other, Consumer Uses: Soil amendments (fertilizers), Not Known or Reasonably Ascertainable, Methods of Manufacturing: REACTION OF TRIMETHYLAMINE AND CONCENTRATED HYDROCHLORIC ACID, FOLLOWED BY TREATMENT WITH ETHYLENE OXIDE UNDER PRESSURE, Klein, Kapp, US patent 2, 623, 901 (1952 to Nopco Chemical). Polymorphism: Collin, J Am Chem Soc 79, 6086 (1957)., Chloine is normally produced by the reaction of trimethylamine, ethylene oxide, and water. Its chloride can be produced by the reaction of trimethylene with chlorohydrin., Formulations, Preparations: FORMS AVAILABLE GENERICALLY: TABLETS 250 MG (CHOLINE BITARTRATES), POWDER (CHOLINE CHLORIDE, CHOLINE DIHYDROGEN CITRATE)., U.S. Production: 2023: 5, 000, 000 - <10, 000 lb, 2022: 5, 2021: 5, 2020: 10, 000 - <50, (1972) 2.47X10+10 GRAMS (MED & TECH GRADE), (1975) 1.76X10+10 GRAMS (ALL GRADES), Ethanaminium, 2-hydroxy-N, N, N-trimethyl-, chloride is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#2627], U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) NEGLIGIBLE, General Manufacturing Information: Oil and Gas Drilling, Extraction, and Support activities, Agriculture, Forestry, Fishing and Hunting, chloride (1:1): ACTIVE, A SELECTED FOOD ADDITIVE CLASSIFIED AS A NUTRIENT AND DIETARY SUPPLEMENT., FROM TABLE, QUALITATIVELY CHOLINE HAS THE SAME PHARMACOLOGICAL ACTIONS AS DOES ACETYLCHOLINE, BUT IT IS FAR LESS ACTIVE., CHOLINE, SINCE HUMAN BREAST MILK CONTAINS 7 MG CHOLINE, 100 KCAL, COMMITTEE ON NUTRITION OF AMERICAN ACADEMY OF PEDIATRICS (1976) RECOMMENDS THE FORTIFICATION OF INFANT FORMULAS TO THIS LEVEL., CHOLINE IS NOT @ PRESENT AN OFFICIAL DRUG. HOWEVER, PREPN OF...CHOLINE CHLORIDE ARE AVAILABLE., ... The dominating industrial process, for choline, is reacting ethylene oxide with trimethylamine and water, or an acid if one of its salts is desired, in a batch or continuous manufacturing process..
Choline Chloride FCC is an inorganic compound with CAS registry number 67-48-1 and molecular formula C5H14NO.Cl (molecular weight 139.62), belonging to the inorganic chemicals segment of chemical raw materials.
CAS number: 67-48-1
Its molecular formula C5H14NO.Cl comprises 5 C, 14 H, 1 N, 1 O, 1 Cl atoms.
Also known as: Choline Chloride FCC · Choline chloride
Category: inorganic chemicals
The CAS registry number of Choline Chloride FCC is 67-48-1.
Molecular formula C5H14NO.Cl, molecular weight 139.62.
It is also registered under: Choline Chloride FCC, Choline chloride.
Recorded applications: Uses: CIR ingredient: Choline Chloride, Therap cat: lipotropic, Therap cat (vet): Nutritional factor. Dietary source of choline (lipotropic factor) in poultry., MEDICATION, MEDICATION (VET), MEDICATION (VET): Animal feed additive derived from agricultural waste or made synthetically. Available as 50% dry feed-grade & 70% soln., Use (kg, approx.) in Germany (2009): >750, Consumption (g per capita, approx.) in Germany (2009): 0.00916, Calculated removal (%): 92.1, Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Flavoring Agents -> JECFA Flavorings Index, Industry Uses: Processing aids, specific to petroleum production, Abrasives, Soil amendments (fertilizers), Other, Consumer Uses: Soil amendments (fertilizers), Not Known or Reasonably Ascertainable, Methods of Manufacturing: REACTION OF TRIMETHYLAMINE AND CONCENTRATED HYDROCHLORIC ACID, FOLLOWED BY TREATMENT WITH ETHYLENE OXIDE UNDER PRESSURE, Klein, Kapp, US patent 2, 623, 901 (1952 to Nopco Chemical). Polymorphism: Collin, J Am Chem Soc 79, 6086 (1957)., Chloine is normally produced by the reaction of trimethylamine, ethylene oxide, and water. Its chloride can be produced by the reaction of trimethylene with chlorohydrin., Formulations, Preparations: FORMS AVAILABLE GENERICALLY: TABLETS 250 MG (CHOLINE BITARTRATES), POWDER (CHOLINE CHLORIDE, CHOLINE DIHYDROGEN CITRATE)., U.S. Production: 2023: 5, 000, 000 - <10, 000 lb, 2022: 5, 2021: 5, 2020: 10, 000 - <50, (1972) 2.47X10+10 GRAMS (MED & TECH GRADE), (1975) 1.76X10+10 GRAMS (ALL GRADES), Ethanaminium, 2-hydroxy-N, N, N-trimethyl-, chloride is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#2627], U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) NEGLIGIBLE, General Manufacturing Information: Oil and Gas Drilling, Extraction, and Support activities, Agriculture, Forestry, Fishing and Hunting, chloride (1:1): ACTIVE, A SELECTED FOOD ADDITIVE CLASSIFIED AS A NUTRIENT AND DIETARY SUPPLEMENT., FROM TABLE, QUALITATIVELY CHOLINE HAS THE SAME PHARMACOLOGICAL ACTIONS AS DOES ACETYLCHOLINE, BUT IT IS FAR LESS ACTIVE., CHOLINE, SINCE HUMAN BREAST MILK CONTAINS 7 MG CHOLINE, 100 KCAL, COMMITTEE ON NUTRITION OF AMERICAN ACADEMY OF PEDIATRICS (1976) RECOMMENDS THE FORTIFICATION OF INFANT FORMULAS TO THIS LEVEL., CHOLINE IS NOT @ PRESENT AN OFFICIAL DRUG. HOWEVER, PREPN OF...CHOLINE CHLORIDE ARE AVAILABLE., ... The dominating industrial process, for choline, is reacting ethylene oxide with trimethylamine and water, or an acid if one of its salts is desired, in a batch or continuous manufacturing process..
Category: Inorganic Chemicals.
Public-database records for Choline Chloride FCC (CAS 67-48-1), reproduced here for independent cross-checking.
| GHS 通报统计 | 53.5% (236 / 441) |
|---|---|
| 已通报的危害声明 | H315 (46%), H319 (46%), H335 (45.6%) |
| 法规与食品接触 | FDA Substance added to food: NUTRIENT SUPPLEMENT FLAVOURING_AGENT: Flavouring Agent Flavoring Agents Savory, Umami No safety concern at current levels of intake when used as a flavouring agent TRS 960-JECFA 73/49 |
|---|---|
| GHS 通报统计 | 53.5% (236 / 441) |
| 熔点 | 305 °C (decomposes) |
|---|---|
| 熔点 | 305 °C |
| LogP | -5.16 |
| pH | 4.7 (10% SOLN IN WATER) |
| CAS 号 | 67-48-1 |
|---|---|
| PubChem CID | 6209 |
| 分子式 | C5H14ClNO |
| 分子量 | 139.08 g/mol |
| IUPAC 名称 | 2-hydroxyethyl(trimethyl)azanium chloride |
| InChIKey | SGMZJAMFUVOLNK-UHFFFAOYSA-M |
| UNII（FDA） | 45I14D8O27 |
| ChEBI 编号 | CHEBI:133341 |
| FEMA 编号 | 4500 |
| JECFA 编号 | 2003 |
CHOLINE CHLORIDE; 67-48-1; Lipotril; Hepacholine; Paresan; 2-Hydroxy-N,N,N-trimethylethanaminium chloride; (2-Hydroxyethyl)trimethylammonium chloride; Hormocline; Biocolina; Luridin chloride; Choline hydrochloride; Neocolina; Bilineurin chloride; Biocoline; Cholinium chloride; Choline, chloride
| 分子量 | 139.62 |
|---|---|
| 氢键供体数 | 1 |
| 氢键受体数 | 2 |
| 可旋转键数 | 2 |
| 精确质量 | 139.0763918 |
| 单同位素质量 | 139.0763918 |
| 拓扑极性表面积 | 20.2 |
| 重原子数 | 8 |
| 形式电荷 | 0 |
| 复杂度 | 46.5 |
氯化胆碱 的 CAS 号为 67-48-1，分子式 C5H14ClNO，分子量 139.08 g/mol。 UNII 45I14D8O27; ChEBI 133341; InChIKey SGMZJAMFUVOLNK-UHFFFAOYSA-M. 熔点: 305 °C (decomposes); 熔点: 305 °C; LogP: -5.16.
Source: PubChem / Wikidata; the batch COA governs where values differ.
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