tinidazole

Public-database records for tinidazole (CAS 19387-91-8), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Solid
• Colorless crystals from benzene
• >37.1 [ug/mL] (The mean of the results at pH 7.4)
• 149.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 161.2 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• Tinidazole is a synthetic antiprotozoal agent. Tinidazole demonstrates activity both in vitro and in clinical infections against the following protozoa: <i>Trichomonas vaginalis</i>, <i>Giardia duodenalis</i> (also termed <i>G. lamblia</i>), and <i>Entamoeba histolytica</i>. Tinidazole does not appear to have activity against most strains of vaginal lactobacilli.

Reported physical properties

How this substance is indexed

Documented uses

• Antiprotozoal and antibacterial activity
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Synthesis: heating 2-methyl-5-nitroimidazole with 2-ethylsulfonylethyl-4-toluenesulfonate for 4 h
• For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients. Also for the treatment of giardiasis caused by G. duodenalis in both adults and pediatric patients older than three years of age and for the treatment of intestinal amebiasis and amebic liver abscess caused by E. histolytica in both adults and pediatric patients older than three years of age.
• Tinidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of bacterial, protozoal and parasitic infections. Tinidazole is a nitroimidazole similar to metronidazole and is likely to have a similar spectrum and frequency of side effects, including a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Anti-Infective Agents; Antibacterial Agents; Antiprotozoal Agents; Nitroimidazoles

Names this substance appears under

tinidazole; 19387-91-8; Fasigyn; Trimonase; Fasigin; Tricolam; 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole; Simplotan; Tinidazol; Sorquetan; Haisigyn; Tinidazolum; 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole; Pletil; CP 12574; timidazole

Computed molecular descriptors

Database abstract

tinidazole · CAS 19387-91-8 · C8H13N3O4S. UNII 033KF7V46H. 熔点: 127-128 °C; 熔点: 127 - 128 °C; 溶解度: 19900.

Source: PubChem / Wikidata; the batch COA governs where values differ.