Voriconazole

Public-database records for Voriconazole (CAS 137234-62-9), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Solid
• Low
• Voriconazole is a fungistatic triazole antifungal used to treat infections by inhibiting fungal growth. It is known to cause hepatotoxic and photosensitivity reactions in some patients.

Reported physical properties

How this substance is indexed

Documented uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
• Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. Voriconazole therapy is associated with transient, asymptomatic serum aminotransferase elevations and is a known cause of clinically apparent acute drug induced liver injury.
• Breast Feeding; Lactation; Milk, Human; Antifungal Agents
• (1) Parenteral - General injections - IV: 200 mg in vial powder for injection; (2) Oral - Liquid: 40 mg per mL powder for oral liquid; (3) Oral - Solid: 50 mg tablet; 200 mg tablet

Names this substance appears under

Voriconazole; 137234-62-9; Vfend; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; UK-109496; Voriconazol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol; Voriconazolum; UK-109,496; UK 109496; JFU09I87TR; NSC-759888; DTXSID5046485; CHEBI:10023; DTXCID3026485; UK109496

Computed molecular descriptors

Database abstract

Voriconazole · CAS 137234-62-9 · C16H14F3N5O. UNII JFU09I87TR. 熔点: 134; 熔点: 127 - 130 °C; 溶解度: 9.78e-02 g/L.

Source: PubChem / Wikidata; the batch COA governs where values differ.