Petinimid

Public-database records for Petinimid (CAS 77-67-8), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Solid
• Crystals from acetone and ether
• WHITE TO OFF-WHITE CRYSTALLINE POWDER OR WAXY SOLID
• CHARACTERISTIC ODOR
• Freely soluble in water
• VERY SLIGHTLY SOL IN SOLVENT HEXANE

Reported physical properties

How this substance is indexed

Documented uses

• For the treatment of petit mal epilepsy.
• The condensation of butanone with cyano ethyl acetate and subsequent reaction with NaCN and H2SO4 gives 2-ethyl-2-methyl-succinic acid, which is ring-closed via the diammonium salt to yield ethosuximide.
• Methyl ethyl ketone + ethyl cyanoacetate + hydrogen cyanide + ammonia (Cope reaction/addition/nitrile hydrolysis/decarboxylation/ester hydrolysis/amide formation)
• (1972) LESS THAN 10+7 GRAMS (CONSUMPTION EST)
• Ethosuximide is FDA-approved for the management of absence seizures in patients 3 or older. Additionally, several studies have suggested ethosuximide may also have some analgesic effects, making it a potential therapy for neuropathic pain.
• Ethosuximide is an succinimide based anticonvulsant commonly used for absence (petit mal) seizures in both adults and children. Ethosuximide has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice.

Names this substance appears under

ethosuximide; 77-67-8; Zarontin; Etosuximida; 3-Ethyl-3-methylpyrrolidine-2,5-dione; 2-Ethyl-2-methylsuccinimide; Ethosuxide; Pyknolepsinum; Emeside; Suxilep; Ethosuccimide; Ethosuccinimide; Atysmal; Suxinutin; Etosuximid; Petinimid

Computed molecular descriptors

Database abstract

Petinimid · CAS 77-67-8 · C7H11NO2. UNII 5SEH9X1D1D. 熔点: 64.5; 熔点: 64 - 65 °C; 熔点: 64.5 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.