Pharmaceutical glycerine (CAS 8013-25-0) — formula C3H8O3, molecular weight 92.09; category organic chemicals.
Documented applications: Uses: CIR ingredient: Glycerin, Used as a solvent, humectant, plasticizer, emollient, sweetener, coating for paper, antifreeze for automobiles, and fluid for gas meters, hydraulic jacks, and shock absorber, Also used to make nitroglycerol (dynamite), cosmetics, soaps, liqueurs, confectioneries, inks, lubricants, glues, and medications, Also used to keep fabrics pliable, to preserve printing on cotton, and to defrost windshields, [HSDB, Merck Index], Pulp and Paper Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], MEDICATION, For Glycerin (USEPA, OPP Pesticide Code: 063507) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The active ingredient is no longer contained in any registered pesticide products ... "cancelled.", Glycerol has a ubiquitous use pattern and can be found in industrial, professional and consumer products. Glycerol is used as a constituent in numerous products and as an intermediate in industrial applications for the manufacture of products such as soaps, detergents and glycerol esters. It is found in consumer products such as pharmaceuticals, tobacco, food and drinks and is present in numerous other products such as paints, resins and paper. For example, it is used as a down hole lubricant in oil and gas fields and as a wetting agent in pesticide formulations. There is no single use which dominates the use pattern., For more Uses (Complete) data for GLYCERIN (9 total), please visit the HSDB record page., Synthetic Polymer MALDI Matrix Compounds, This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation., Use Classification: EPA Safer Chemical Functional Use Classes -> Solvents, Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern, Fragrance Ingredients, Flavouring Agent -> FLAVOURING_AGENTFood Additives -> CARRIER_SOLVENT, EMULSIFIER, HUMECTANT, THICKENER -> JECFA Functional Classes, Plastics -> Polymer Type -> N.a., Cosmetics -> Denaturant, Solvent, Humectant, Plastics -> Other functions -> Slip promoter, SOLVENTS, Industry Uses: Flow promoter, Diluent, Not Known or Reasonably Ascertainable, Emulsifier, Anti-slip agent, Intermediate, Other, Lubricating agent, Flavoring and nutrient, Anti-freeze agent, Abrasives, Dust suppressant, Fuel agents, Processing aids not otherwise specified, Solubility enhancer, Monomers, Tanning agents not otherwise specified, Surfactant (surface active agent), Consumer Uses: Cleaning agent, Stabilizing agent, Soil amendments (fertilizers), Adhesion, cohesion promoter, Etching agent, Softener and conditioner, Freeze-thaw additive, Household Products: Information on 2656 consumer products that contain Glycerin in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Hobby, Craft, • Home Maintenance, • Home Office, • Inside the Home, • Landscaping, Yard, • Personal Care, • Pesticides, • Pet Care, Methods of Manufacturing: Production from allyl chloride: ... This method became available once the high-temperature chlorination of propene to allyl chloride could be controlled properly. The allyl chloride produced is oxidized with hypochlorite to dichlorohydrin, which is converted without isolation to epichlorohydrin by ring closure with calcium or sodium hydroxide. Hydrolysis to glycerol is carried out with sodium hydroxide or sodium carbonate. Epichlorohydrin is hydrolyzed to glycerol at 80 - 200 °C with a 10 - 15% aqueous solution of sodium hydroxide or sodium carbonate at atmospheric or overpressure. The residence time in one or a series of several closed, continuously operating reactors amounts to several minutes or several hours depending on the plant concerned. The yield of dilute (10 - 25%) glycerol solution is > 98%. The solution contains 5 - 10% sodium chloride and less than 2% of other impurities. This aqueous glycerol solution containing sodium chloride is evaporated in a multistage evaporation plant under vacuum to a glycerol concentration of > 75%, precipitated sodium chloride is separated at the same time. The glycerol solution is then distilled under high vacuum (about 0.5 - 1.0 kPa), co-distilled water is separated by fractional condensation. Residual inorganic salts and higher oligomers of glycerol remaining after the evaporation must be worked up further or discarded. The glycerol, practically free of water, is treated further to remove colored impurities and odorous material, this can be performed, for example, with activated carbon., Production from acrolein: ... Propene is oxidized to acrolein, which is then reduced to allyl alcohol (Meerwein-Ponndorf-Verley reduction). The allyl alcohol is epoxidized with hydrogen peroxide, and the resulting glycidol is hydrolyzed to glycerol., Production from propylene oxide: ... Propene is epoxidized to propylene oxide, which is then isomerized to allyl alcohol by the Progil process. A second epoxidation is carried out with peracetic acid, Fermentation of sugar: ... The fermentation, is, ... interrupted at the glyceraldehyde 3-phosphate stage with sodium carbonate or with alkali or alkaline earth sulfites. After reduction to glycerol phosphate, glycerol is obtained in yields up to 25% by hydrolysis., For more Methods of Manufacturing (Complete) data for GLYCERIN (9 to.
Pharmaceutical glycerine is a carbon-based organic compound with CAS registry number 8013-25-0 and molecular formula C3H8O3 (molecular weight 92.09), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 8013-25-0
Its molecular formula C3H8O3 comprises 3 C, 8 H, 3 O atoms.
Also known as: Pharmaceutical glycerine · GLYCERINE USP · Hydrogel · Industrial glycerol
Category: organic chemicals
The CAS registry number of Pharmaceutical glycerine is 8013-25-0.
Molecular formula C3H8O3, molecular weight 92.09.
It is also registered under: Pharmaceutical glycerine, GLYCERINE USP, Hydrogel, Industrial glycerol.
Recorded applications: Uses: CIR ingredient: Glycerin, Used as a solvent, humectant, plasticizer, emollient, sweetener, coating for paper, antifreeze for automobiles, and fluid for gas meters, hydraulic jacks, and shock absorber, Also used to make nitroglycerol (dynamite), cosmetics, soaps, liqueurs, confectioneries, inks, lubricants, glues, and medications, Also used to keep fabrics pliable, to preserve printing on cotton, and to defrost windshields, [HSDB, Merck Index], Pulp and Paper Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], MEDICATION, For Glycerin (USEPA, OPP Pesticide Code: 063507) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The active ingredient is no longer contained in any registered pesticide products ... "cancelled.", Glycerol has a ubiquitous use pattern and can be found in industrial, professional and consumer products. Glycerol is used as a constituent in numerous products and as an intermediate in industrial applications for the manufacture of products such as soaps, detergents and glycerol esters. It is found in consumer products such as pharmaceuticals, tobacco, food and drinks and is present in numerous other products such as paints, resins and paper. For example, it is used as a down hole lubricant in oil and gas fields and as a wetting agent in pesticide formulations. There is no single use which dominates the use pattern., For more Uses (Complete) data for GLYCERIN (9 total), please visit the HSDB record page., Synthetic Polymer MALDI Matrix Compounds, This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation., Use Classification: EPA Safer Chemical Functional Use Classes -> Solvents, Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern, Fragrance Ingredients, Flavouring Agent -> FLAVOURING_AGENTFood Additives -> CARRIER_SOLVENT, EMULSIFIER, HUMECTANT, THICKENER -> JECFA Functional Classes, Plastics -> Polymer Type -> N.a., Cosmetics -> Denaturant, Solvent, Humectant, Plastics -> Other functions -> Slip promoter, SOLVENTS, Industry Uses: Flow promoter, Diluent, Not Known or Reasonably Ascertainable, Emulsifier, Anti-slip agent, Intermediate, Other, Lubricating agent, Flavoring and nutrient, Anti-freeze agent, Abrasives, Dust suppressant, Fuel agents, Processing aids not otherwise specified, Solubility enhancer, Monomers, Tanning agents not otherwise specified, Surfactant (surface active agent), Consumer Uses: Cleaning agent, Stabilizing agent, Soil amendments (fertilizers), Adhesion, cohesion promoter, Etching agent, Softener and conditioner, Freeze-thaw additive, Household Products: Information on 2656 consumer products that contain Glycerin in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Hobby, Craft, • Home Maintenance, • Home Office, • Inside the Home, • Landscaping, Yard, • Personal Care, • Pesticides, • Pet Care, Methods of Manufacturing: Production from allyl chloride: ... This method became available once the high-temperature chlorination of propene to allyl chloride could be controlled properly. The allyl chloride produced is oxidized with hypochlorite to dichlorohydrin, which is converted without isolation to epichlorohydrin by ring closure with calcium or sodium hydroxide. Hydrolysis to glycerol is carried out with sodium hydroxide or sodium carbonate. Epichlorohydrin is hydrolyzed to glycerol at 80 - 200 °C with a 10 - 15% aqueous solution of sodium hydroxide or sodium carbonate at atmospheric or overpressure. The residence time in one or a series of several closed, continuously operating reactors amounts to several minutes or several hours depending on the plant concerned. The yield of dilute (10 - 25%) glycerol solution is > 98%. The solution contains 5 - 10% sodium chloride and less than 2% of other impurities. This aqueous glycerol solution containing sodium chloride is evaporated in a multistage evaporation plant under vacuum to a glycerol concentration of > 75%, precipitated sodium chloride is separated at the same time. The glycerol solution is then distilled under high vacuum (about 0.5 - 1.0 kPa), co-distilled water is separated by fractional condensation. Residual inorganic salts and higher oligomers of glycerol remaining after the evaporation must be worked up further or discarded. The glycerol, practically free of water, is treated further to remove colored impurities and odorous material, this can be performed, for example, with activated carbon., Production from acrolein: ... Propene is oxidized to acrolein, which is then reduced to allyl alcohol (Meerwein-Ponndorf-Verley reduction). The allyl alcohol is epoxidized with hydrogen peroxide, and the resulting glycidol is hydrolyzed to glycerol., Production from propylene oxide: ... Propene is epoxidized to propylene oxide, which is then isomerized to allyl alcohol by the Progil process. A second epoxidation is carried out with peracetic acid, Fermentation of sugar: ... The fermentation, is, ... interrupted at the glyceraldehyde 3-phosphate stage with sodium carbonate or with alkali or alkaline earth sulfites. After reduction to glycerol phosphate, glycerol is obtained in yields up to 25% by hydrolysis., For more Methods of Manufacturing (Complete) data for GLYCERIN (9 to.
Category: Organic Chemicals.
Public-database records for Pharmaceutical glycerine (CAS 8013-25-0), reproduced here for independent cross-checking.
| GHS notification summary | 98.3% (5522 / 5617) |
|---|
This chemical does not meet GHS hazard criteria for 98.3% (5522 of 5617) of all reports.
Reported as not meeting GHS hazard criteria by 5522 of 5617 companies (only 1.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
| Regulatory & Food Contact | FDA Substance added to food: ANTICAKING AGENT OR FREE-FLOW AGENT, DRYING AGENT, EMULSIFIER OR EMULSIFIER SALT FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS FLAVOURING_AGENTFood Additives -> CARRIER_SOLVENT; EMULSIFIE: Flavouring Agent GLYCERIN, SYNTHETIC ANTICAKING AGENT OR FREE-FLOW AGENT, DRYING AGENT, EMULSIFIER OR EMULSIFIER SALT, HUMECTANT, MASTICATORY SUBST Monoglycerides |
|---|---|
| GHS notification summary | 98.3% (5522 / 5617) |
| 沸点 | 290 °C (decomposes) |
|---|---|
| 沸点 | 290 °C |
| 沸点 | 290 °C @760 [mm Hg] |
| 熔点 | 64 °F (NTP, 1992) |
| 熔点 | 18.1 °C |
| 熔点 | 20 °C |
| 熔点 | 18 °C |
| 熔点 | 64 °F |
| 闪点 | 320 °F (NTP, 1992) |
| 闪点 | 177 °C |
| CAS Registry Number | 8013-25-0 |
|---|---|
| PubChem CID | 753 |
| 分子式 | C3H8O3 |
| IUPAC 名称 | propane-1,2,3-triol |
| UNII（FDA） | PDC6A3C0OX |
| FEMA 编号 | 2525 |
| JECFA 编号 | 909 |
glycerol; glycerin; 56-81-5; Glycerine; 1,2,3-Propanetriol; Glycyl alcohol; Trihydroxypropane; Glyceritol; Osmoglyn; 1,2,3-trihydroxypropane; Glyrol; Glysanin; Grocolene; Ophthalgan; Glycerinum; Vitrosupos
| 分子量 | 92.09 |
|---|---|
| XLogP3 | -1.8 |
| 氢键供体数 | 3 |
| 氢键受体数 | 3 |
| 可旋转键数 | 2 |
| 精确质量 | 92.047344113 |
| 单同位素质量 | 92.047344113 |
| 拓扑极性表面积 | 60.7 |
| 重原子数 | 6 |
| 形式电荷 | 0 |
Industrial glycerol · CAS 8013-25-0 · C3H8O3. UNII PDC6A3C0OX. 沸点: 290 °C (decomposes); 沸点: 290 °C; 沸点: 290 °C @760 [mm Hg].
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd. · Reply within one business day.