ethopropazine hydrochloride

Public-database records for ethopropazine hydrochloride (CAS 1094-08-2), reproduced here for independent cross-checking.

Physical description and handling notes

• Solid
• 174.37 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 167.61 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 172.03 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Reported physical properties

How this substance is indexed

Documented uses

• Profenamine is indicated in the symptomatic treatment of drug-induced extrapyramidal reactions and of the manifestations (rigidity, akinesia, sialorrhea, oculogyric crisis, tremor, etc.) of Parkinson's disease of encephalitic, arteriosclerotic or idiopathic origin. It is also used to control severe reactions to certain medicines such as reserpine.
• Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
• Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
• Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
• Well-absorbed from the gastrointestinal tract.

Names this substance appears under

ethopropazine; Profenamine; Ethopromazine; 522-00-9; Profenaminum; Profenamina; 2-Diethylamino-1-propyl-N-dibenzoparathiazine; N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine; W-483; RP-3356; SC-2538; 7WI4P02YN1; (+-)-Ethopropazine; 10-[2-(Diethylamino)propyl]phenothiazine; 10-[2-(Diethylamino)-1-Propyl]phenothiazine; 10H-Phenothiazine-10-ethanamine, N,N-diethyl-alpha-methyl-

Computed molecular descriptors

Database abstract

ethopropazine hydrochloride · CAS 1094-08-2 · C19H24N2S. UNII 7WI4P02YN1. 熔点: 166-168; 熔点: 64.5 °C; 溶解度: 0.693.

Source: PubChem / Wikidata; the batch COA governs where values differ.