Enasidenib

Name: Enasidenib
Brand: Jinan Shenghe Chemical Co., Ltd.
SKU: 18373

CAS 1446502-11-9C19H17F6N7OMW 473.4

Enasidenib (CAS 1446502-11-9) — formula C19H17F6N7O, molecular weight 473.4; category organic chemicals.

Specifications

CAS Number1446502-11-9

Molecular FormulaC19H17F6N7O

Molecular Weight473.4

LogP3.5

CategoryOrganic Chemicals

Purchase Profile

What this product is

Enasidenib is a carbon-based organic compound with CAS registry number 1446502-11-9 and molecular formula C19H17F6N7O (molecular weight 473.4), belonging to the organic chemicals segment of chemical raw materials.

Identification

CAS number: 1446502-11-9

Its molecular formula C19H17F6N7O comprises 19 C, 17 H, 6 F, 7 N, 1 O atoms.

Also known as: Enasidenib

Category: organic chemicals

Frequently Asked Questions

What is the CAS number of Enasidenib?

The CAS registry number of Enasidenib is 1446502-11-9.

What is the molecular formula and molecular weight of Enasidenib?

Molecular formula C19H17F6N7O, molecular weight 473.4.

What other names is Enasidenib known by?

It is also registered under: Enasidenib.

Which category does Enasidenib belong to?

Category: Organic Chemicals.

PubChem Public Data

Public-database records for Enasidenib (CAS 1446502-11-9), reproduced here for independent cross-checking.

Safety classification and hazard statements

Reported hazard statements	H360 (50%), H373 (100%), H413 (50%)

H360 (50%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H361f (50%): Suspected of damaging fertility [Warning Reproductive toxicity]

How this substance is indexed

CAS Registry Number	1446502-11-9
PubChem CID	89683805
分子式	C19H17F6N7O
IUPAC 名称	2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol
UNII（FDA）	3T1SS4E7AG

Documented uses

Enasidenib is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test.
Enasidenib is an orally available small molecule inhibitor of mutant isocitrate dehydrogenase-2 that is used in the therapy of selected cases of acute myelogenous leukemia (AML). Enasidenib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Isocitrate Dehydrogenase Inhibitors
Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
Take at the same time every day.

Names this substance appears under

Enasidenib; 1446502-11-9; CC-90007 Free Base; enasidenibum; 3T1SS4E7AG; CHEBI:145374; DTXSID801027942; RefChem:58279; L01XX59; DTXCID401513509; 107-597-8; AG-221; IDHIFA; AG-221 (Enasidenib); Enasidenib [INN]; AG 221

Computed molecular descriptors

分子量	473.4
XLogP3	3.5
氢键供体数	3
氢键受体数	14
可旋转键数	6
精确质量	473.13987716
单同位素质量	473.13987716
拓扑极性表面积	109
重原子数	33
形式电荷	0

Database abstract

Enasidenib · CAS 1446502-11-9 · C19H17F6N7O. UNII 3T1SS4E7AG.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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