Gadoteridol

Public-database records for Gadoteridol (CAS 120066-54-8), reproduced here for independent cross-checking.

Physical description and handling notes

• White solid obtained as an aggregate clump of fine needle-like micro-crystals from methanol/acetone
• 溶解度 (mg/mL): methanol 119, isopropanol 41, dimethylformamide 10.1, acetonitrile 6.1, methylene chloride 5.2, ethyl acetate 0.5, acetone 0.4, hexane 0.2, toluene 0.3
• Osmolality (37 °C): 630 mOsM/kg water; viscosity (cP): 2.0 (20 °C), 1.3 (37 °C); density at 25 °C 1.140. /Gadoteridol injection/
• log Kow = -3.68 (octanol/water); logP = -1.98 (butanol/water), at pH 7
• Hydrophilic
• ProHance (Gadoteridol) Injection is a clear, colorless to slightly yellow solution containing 279.3 mg/mL of gadoteridol in rubber stoppered vials.

Reported physical properties

How this substance is indexed

Documented uses

• Injectable contrast Medium for Magnetic Resonance Imaging (MRI)
• Typical contrast agents are gadolinium-based compounds that possess a higher linear attenuation coefficient than soft tissues. /Contrast agents/
• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Preparation: M. F. Tweedle et al, European Patent Office patent 292689; eidem, United States of America patent 4885363 (1988, 1989, both to Squibb).
• Gadoteridol is indicated for use with magnetic resonance imaging (MRI) in order to visualize lesions with disrupted blood-brain barrier and/or abnormal vascularity in the brain, spine, and associated tissues in adult and pediatric patients, including term neonates. It is also indicated for visualization of lesions in the head and neck in adult patients.

Names this substance appears under

GADOTERIDOL; ProHance; 120066-54-8; Gadolinium-HP-DO3A; Prohance Multipack; DTXSID2048662; GD-HP-DO 3A; SQ-32692; Gd-HPDO3A; Gd-HP-DO3A; Gadolinium-HP-Do 3A; DTXCID5028588; 0199MV609F; NSC-760055; HSDB 7549; SQ 32,692

Computed molecular descriptors

Database abstract

Gadoteridol · CAS 120066-54-8 · C17H29GdN4O7. UNII 0199MV609F. 熔点: >225 °C; 溶解度: In water, 737 mg/mL.

Source: PubChem / Wikidata; the batch COA governs where values differ.