Hydroxy Chloroquine

Public-database records for Hydroxy Chloroquine (CAS 118-42-3), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Solid
• 177.57 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 174.27 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 169.89 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 180.2 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Reported physical properties

How this substance is indexed

Documented uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Consumption (g per capita) in the USA (2002): 0.0819
• For the suppressive treatment and treatment of acute attacks of malaria due to <i>Plasmodium vivax</i>, <i>P. malariae</i>, <i>P. ovale</i>, and susceptible strains of <i>P. falciparum</i>. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.
• Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by _P. falciparum_, _P. malariae_, _P. ovale_, or _P. vivax_), chronic discoid lupus erythematosus, systemic lupus erythematosus, acute rheumatoid arthritis, and chronic rheumatoid arthritis.
• Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury.

Names this substance appears under

hydroxychloroquine; 118-42-3; Oxichloroquine; Oxychlorochin; Hidroxicloroquina; oxichlorochine; Polirreumin; Hydroxychloroquinum; 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; Dolquine; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 4QWG6N8QKH; 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline; CHEBI:5801; NSC4375

Computed molecular descriptors

Database abstract

Hydroxy Chloroquine · CAS 118-42-3 · C18H26ClN3O. UNII 4QWG6N8QKH. 熔点: 89-91; 熔点: 90 °C; 溶解度: 2.61e-02 g/L.

Source: PubChem / Wikidata; the batch COA governs where values differ.