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Home › Product Catalog › Hexamethylmelamine

Hexamethylmelamine

CAS 645-05-6C9H18N6MW 210.28

Hexamethylmelamine (CAS 645-05-6) — formula C9H18N6, molecular weight 210.28; category organic chemicals.

Specifications

CAS Number645-05-6
Molecular FormulaC9H18N6
Molecular Weight210.28
Melting Point168
LogP2.7
ApplicationsUses: Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and, or alkylating agent based combination., Experimental insect chemosterilant., THERAP CAT: Antineoplastic, MEDICATION, Methods of Manufacturing: Production process: H. von Brachel, H. Kindler, DE 1240870, eidem, US 3424752 (1967, 1969 both to Casella Farbwerke), Formulations, Preparations: U.S.: 50 mg (Rx) [Hexalen (lactose)]. Canada: 50 mg (Rx) [Hexalen].
CategoryOrganic Chemicals

Where it is used

Documented applications: Uses: Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and, or alkylating agent based combination., Experimental insect chemosterilant., THERAP CAT: Antineoplastic, MEDICATION, Methods of Manufacturing: Production process: H. von Brachel, H. Kindler, DE 1240870, eidem, US 3424752 (1967, 1969 both to Casella Farbwerke), Formulations, Preparations: U.S.: 50 mg (Rx) [Hexalen (lactose)]. Canada: 50 mg (Rx) [Hexalen]..

Purchase Profile

What this product is

Hexamethylmelamine is a carbon-based organic compound with CAS registry number 645-05-6 and molecular formula C9H18N6 (molecular weight 210.28), belonging to the organic chemicals segment of chemical raw materials.

Identification

CAS number: 645-05-6

Its molecular formula C9H18N6 comprises 9 C, 18 H, 6 N atoms.

Also known as: Hexamethylmelamine · altretamine

Category: organic chemicals

Frequently Asked Questions

What is the CAS number of Hexamethylmelamine?

The CAS registry number of Hexamethylmelamine is 645-05-6.

What is the molecular formula and molecular weight of Hexamethylmelamine?

Molecular formula C9H18N6, molecular weight 210.28.

What other names is Hexamethylmelamine known by?

It is also registered under: Hexamethylmelamine, altretamine.

What are the documented applications of Hexamethylmelamine?

Recorded applications: Uses: Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and, or alkylating agent based combination., Experimental insect chemosterilant., THERAP CAT: Antineoplastic, MEDICATION, Methods of Manufacturing: Production process: H. von Brachel, H. Kindler, DE 1240870, eidem, US 3424752 (1967, 1969 both to Casella Farbwerke), Formulations, Preparations: U.S.: 50 mg (Rx) [Hexalen (lactose)]. Canada: 50 mg (Rx) [Hexalen]..

Which category does Hexamethylmelamine belong to?

Category: Organic Chemicals.

PubChem Public Data

Public-database records for Hexamethylmelamine (CAS 645-05-6), reproduced here for independent cross-checking.

Safety classification and hazard statements

Reported hazard statementsH302 (100%), H315 (100%), H319 (100%), H335 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

Physical description and handling notes

  • Hexamethylmelamine is a colorless crystalline solid. Insoluble in water. (NTP, 1992)
  • Solid
  • Needles from absolute ethanol
  • Insoluble (NTP, 1992)
  • Soluble in acetone
  • Bulk: The bulk drug is stable at room temperature. Solution: Aqueous solutions at pH 4, 7, and 10 are stable for 24 hours at room temperature (UV).

Reported physical properties

熔点168
熔点172-174 °C
熔点172 - 174 °C
溶解度91
溶解度In water, 91 mg/L at 25 °C
溶解度3.10e+00 g/L
溶解度Water 0.92 (mg/mL)
溶解度Benzene 106 (mg/mL)
溶解度CHCL3 220 (mg/mL)
溶解度EtOAc 52 (mg/mL)

How this substance is indexed

CAS Registry Number645-05-6
PubChem CID2123
分子式C9H18N6
IUPAC 名称2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
UNII（FDA）Q8BIH59O7H

Documented uses

  • Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent based combination.
  • Experimental insect chemosterilant.
  • Production process: H. von Brachel, H. Kindler, DE 1240870; eidem, US 3424752 (1967, 1969 both to Casella Farbwerke)
  • For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
  • Altretamine is an orally administered alkylating agent, formerly known as hexamethylmelamine, which is currently used as a secondary therapy for advanced ovarian carcinoma. Altretamine therapy has been associated with low rates of serum enzyme elevations during therapy and with rare instances of acute, clinically apparent injury.
  • Antineoplastic Agents, Alkylating Agents

Names this substance appears under

altretamine; 645-05-6; HEXAMETHYLMELAMINE; Hexalen; Hexastat; Hemel; Altretamina; Melamine, hexamethyl-; Altretaminum; ENT 50852; 2,4,6-Tris(dimethylamino)-s-triazine; NCI-C50259; 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine; NSC 13875; NSC-13875; DTXSID4022579

Computed molecular descriptors

分子量210.28
XLogP32.7
氢键供体数0
氢键受体数6
可旋转键数3
精确质量210.15929460
单同位素质量210.15929460
拓扑极性表面积48.4
重原子数15
形式电荷0

Database abstract

Hexamethylmelamine · CAS 645-05-6 · C9H18N6. UNII Q8BIH59O7H. 熔点: 168; 熔点: 172-174 °C; 熔点: 172 - 174 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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