Lefunomide (CAS 75706-12-6) — formula C12H9F3N2O2, molecular weight 270.21; category organic chemicals.
Documented applications: Uses: Medication: antirheumatic, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 274, Use (kg) in USA (2002): 221, Consumption (g per capita, approx.) in Germany (2009): 0.00305, exact) in Germany (2009): 0.00334, Consumption (g per capita) in the USA (2002): 0.000783, Calculated removal (%): 10.4, Formulations, Preparations: Oral: Tablets 10 mg Arava (Aventis), 20 mg Arava (Aventis), 100 mg Arava (Aventis)., General Manufacturing Information: Preparation: F.J. Kaemmerer, R. Schleyerbach, DE 2854439, eidem, US 4284786 (1980, 1981 both to Hoechst), Information available in 2004 indicated that Leflunomide was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Croatia, Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Germany, Greece, Guatemala, Hong Kong, Hungary, India, Indonesia, Ireland, Israel, Italy, Japan, Malaysia, Mexico, Netherlands, Norway, New Zealand, Panama, Portugal, Romania, Singapore, Slovenia, South Africa, Spain, Sweden, Switzerland, Thailand, United Kingdom, USA, Yugoslavia (1, 2).
Lefunomide is a carbon-based organic compound with CAS registry number 75706-12-6 and molecular formula C12H9F3N2O2 (molecular weight 270.21), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 75706-12-6
Its molecular formula C12H9F3N2O2 comprises 12 C, 9 H, 3 F, 2 N, 2 O atoms.
Also known as: Lefunomide · leflunomide
Category: organic chemicals
The CAS registry number of Lefunomide is 75706-12-6.
Molecular formula C12H9F3N2O2, molecular weight 270.21.
It is also registered under: Lefunomide, leflunomide.
Recorded applications: Uses: Medication: antirheumatic, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 274, Use (kg) in USA (2002): 221, Consumption (g per capita, approx.) in Germany (2009): 0.00305, exact) in Germany (2009): 0.00334, Consumption (g per capita) in the USA (2002): 0.000783, Calculated removal (%): 10.4, Formulations, Preparations: Oral: Tablets 10 mg Arava (Aventis), 20 mg Arava (Aventis), 100 mg Arava (Aventis)., General Manufacturing Information: Preparation: F.J. Kaemmerer, R. Schleyerbach, DE 2854439, eidem, US 4284786 (1980, 1981 both to Hoechst), Information available in 2004 indicated that Leflunomide was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Croatia, Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Germany, Greece, Guatemala, Hong Kong, Hungary, India, Indonesia, Ireland, Israel, Italy, Japan, Malaysia, Mexico, Netherlands, Norway, New Zealand, Panama, Portugal, Romania, Singapore, Slovenia, South Africa, Spain, Sweden, Switzerland, Thailand, United Kingdom, USA, Yugoslavia (1, 2).
Category: Organic Chemicals.
Public-database records for Lefunomide (CAS 75706-12-6), reproduced here for independent cross-checking.
| Reported hazard statements | H301 (99.3%), H315 (96.3%), H319 (96.3%), H335 (96.3%) |
|---|
H301 (99.3%): Toxic if swallowed [Danger Acute toxicity, oral]
H315 (96.3%): Causes skin irritation [Warning Skin corrosion/irritation]
| 熔点 | 165-166 °C |
|---|---|
| 熔点 | 166.5 °C |
| 熔点 | 165 - 166 °C |
| 溶解度 | 21 |
| 溶解度 | 8.44e-02 g/L |
| LogP | 2.8 |
| LogP | 3.9 |
| CAS Registry Number | 75706-12-6 |
|---|---|
| PubChem CID | 3899 |
| 分子式 | C12H9F3N2O2 |
| IUPAC 名称 | 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide |
| UNII（FDA） | G162GK9U4W |
leflunomide; 75706-12-6; Arava; Leflunomida; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomidum; HWA-486; Repso; leflunomide medac; SU101; Leflunomide teva; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; SU-101; DTXSID9023201; Leflunomide winthrop; SULOL
| 分子量 | 270.21 |
|---|---|
| XLogP3 | 2.5 |
| 氢键供体数 | 1 |
| 氢键受体数 | 6 |
| 可旋转键数 | 2 |
| 精确质量 | 270.06161202 |
| 单同位素质量 | 270.06161202 |
| 拓扑极性表面积 | 55.1 |
| 重原子数 | 19 |
| 形式电荷 | 0 |
Lefunomide · CAS 75706-12-6 · C12H9F3N2O2. UNII G162GK9U4W. 熔点: 165-166 °C; 熔点: 166.5 °C; 熔点: 165 - 166 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
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