prostaglandin F(2)(alpha) tris salt

Public-database records for prostaglandin F(2)(alpha) tris salt (CAS 38562-01-5), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2_alpha. Prostaglandin F2_alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.

Reported physical properties

How this substance is indexed

Documented uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
• Non-steroidal chemical compounds with abortifacient activity.
• Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
• Slowly absorbed from the amniotic fluid into systemic circulation.
• Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.

Names this substance appears under

dinoprost tromethamine; 38562-01-5; Dinoprost trometamol; Prostin F2 alpha; PGF2alpha THAM; Lutalyse; PGF2-alpha tham; Prostaglandin F2alpha tham; Prostaglandin F2-alpha THAM; Prostamate; Prostaglandin F2a tromethamine; PGF2A THAM; U-14,583E; PGF2ALPHA-THAM; DTXSID1045582; CT6BBQ5A68

Computed molecular descriptors

Database abstract

prostaglandin F(2)(alpha) tris salt · CAS 38562-01-5 · C24H45NO8. UNII CT6BBQ5A68. 熔点: 100-101; 溶解度: 0.2; LogP: -0.12.

Source: PubChem / Wikidata; the batch COA governs where values differ.