Trihexylphenedyl

Public-database records for Trihexylphenedyl (CAS 144-11-6), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• Solid
• Crystals; decomp at 258.5 °C; pH of 1% aq soln 5.5-6.0; solubility (g/100 mL): water at 25 °C 1.0, alcohol 6, chloroform 5; more soluble in methanol; very slightly soluble in ether, benzene /Hydrochloride/
• 175.1 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated]
• 169.71 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 178.37 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 173.72 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Reported physical properties

How this substance is indexed

Documented uses

• Synthetic antispasmodic ... adjunct in the treatment of all forms of parksinonism (postencephalitic, arteriosclerotic, and idiopathic) /Trihexylphenidyl hydrochloride/
• THERAP CAT: Antiparkinsonian /Trihexylphenidyl hydrochloride/
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Consumption (g per capita) in France (2004): 0.00425
• Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.

Names this substance appears under

trihexyphenidyl; Benzhexol; 144-11-6; Triphenidyl; Trihexyphenidyle; Benzhexolum; Trihexifenidilo; Trihexyphenidylum; Apo-Trihex; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 6RC5V8B7PO; NSC-12268; DTXSID4023705; 5-20-02-00231 (Beilstein Handbook Reference); Triesifenidile

Computed molecular descriptors

Database abstract

Trihexylphenedyl · CAS 144-11-6 · C20H31NO. UNII 6RC5V8B7PO. 熔点: 115; 熔点: 114 °C; 熔点: 258.5 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.